ArticleThe Journal of experimental medicine1995
Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Expression, purification, crystallization and preliminary X-ray diffraction analysis of nurse shark β2-microglobulin.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain.Immunogenetics · 2004Article
- A novel quality control compartment derived from the endoplasmic reticulum.Molecular biology of the cell · 2001Article
- Biosynthesis of HLA-C heavy chains in melanoma cells with multiple defects in the expression of HLA-A, -B, -C molecules.British journal of cancer · 1999Article
- Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide.The Journal of experimental medicine · 1999Article
- Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.The Journal of experimental medicine · 1998Article
- HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice.The Journal of experimental medicine · 1997Article
- A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.The EMBO journal · 1997Article
- The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.The Journal of experimental medicine · 1997Article
- Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies.The Journal of experimental medicine · 1996Article
- Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys.Journal of virology · 1996Article
- MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains.The Journal of experimental medicine · 1996Article
- Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules.The EMBO journal · 1996Article
- Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Class I major histocompatibility complex molecules require both beta 2-microglobulin (beta 2m) and peptide for efficient intracellular transport. With the exception of H-2Db and Ld, class I heavy chains have not been detectable at the surface of cells lacking beta 2m. We show that properly conformed class I heavy chains can be detected in a terminally glycosylated form indicative of cell surface expression in H-2b, H-2d, and H-2s beta 2m-/- concanavalin A (Con A)-stimulated splenocytes incubated at reduced temperature. Furthermore, we demonstrate the presence of Kb molecules at the surface of beta 2m-/- cells cultured at 37 degrees C. The mode of assembly of class I molecules encompasses two major pathways: binding of peptide to preformed "empty" heterodimers, and binding of peptide to free heavy chains, followed by recruitment of beta 2m. In support of the existence of the latter pathway, we provide evidence for a role of peptide in intracellular transport of free class I heavy chains, through analysis of Con A-stimulated splenocytes from transporter associated with antigen processing 1 (TAP1)-/-, beta 2m-/-, and double-mutant TAP1/beta 2m-/- mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.