ArticleInfection and immunity1995
Degradation of humoral host defense by Candida albicans proteinase.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 115 citations in OpenAlex.
- Synergistic effects ofFrontiers in cellular and infection microbiology · 2025Article
- Secreted Aspartic Proteinases: Key Factors inInternational journal of molecular sciences · 2024Review
- Secreted aspartyl protease 3 regulated by the Ras/cAMP/PKA pathway promotes the virulence ofFrontiers in cellular and infection microbiology · 2023Article
- Host's Immunity andMicroorganisms · 2022Review
- From Naturally-Sourced Protease Inhibitors to New Treatments for Fungal Infections.Journal of fungi (Basel, Switzerland) · 2021Review
- Candida sp. Infections in Patients with Diabetes Mellitus.Journal of clinical medicine · 2019Review
- Estimation of biofilm, proteinase & phospholipase production of theThe Indian journal of medical research · 2017Article
- Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.Journal of microbiology (Seoul, Korea) · 2016Review
- Article
- Impact of Staphylococcus aureus on pathogenesis in polymicrobial infections.Infection and immunity · 2014Review
- Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1, HWP1 and SAP2 gene expression.BMC microbiology · 2014Article
- Profiling of Candida albicans gene expression during intra-abdominal candidiasis identifies biologic processes involved in pathogenesis.The Journal of infectious diseases · 2013Article
- The link between infection and cancer: tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect.Cancer science · 2013Review
- Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease.PloS one · 2012Article
- Fungal proteases and their pathophysiological effects.Mycopathologia · 2011Review
- Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.Infection and immunity · 2010Article
- The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.Infection and immunity · 2009Article
- Ageing exacerbates damage of systemic and salivary neutrophils from patients presenting Candida-related denture stomatitis.Immunity & ageing : I & A · 2009Article
- Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.Mycoses · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of an extracellular proteinase from the pathogenic yeast Candida albicans on the bactericidal and opsonizing activities of human serum was studied. The ability of human polymorphonuclear leukocytes to kill Staphylococcus aureus was greatly reduced when the bacteria were opsonized with human serum treated with the proteinase. The reduction in the opsonizing activity of human serum was attributed to degradation of the Fc portion of immunoglobulin G by the action of C. albicans proteinase as determined by immunoprecipitation reaction. However, the Fab portion of immunoglobulin G was resistant to proteolysis by the proteinase. A clear reduction in the bactericidal activity of human serum against Escherichia coli was observed when the serum was treated with C. albicans proteinase. The reduction of serum bactericidal activity was attributed to the degradation of complement C3 by proteolysis by the proteinase as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, while C5 resisted the action of the proteinase. As determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the proteinase also degrades endogenous proteinase inhibitors, such as alpha 2 macroglobulin and alpha 1 proteinase inhibitor, which are involved in regulating inflammation. These results suggest that destruction of a host's defense-oriented or regulatory proteins facilitates debilitation of the infected host.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.