ArticleMolecular biology of the cell1994
Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.
Article in Molecular biology of the cell, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 50 citations in OpenAlex.
- Transcriptional down-regulation of epidermal growth factor (EGF) receptors by nerve growth factor (NGF) in PC12 cells.Journal of molecular neuroscience : MN · 2014Review
- A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia.Molecular genetics & genomic medicine · 2014Article
- Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons.PloS one · 2013Article
- Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.Molecular biology of the cell · 2008Article
- Ebp1 isoforms distinctively regulate cell survival and differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- E2F2 converts reversibly differentiated PC12 cells to an irreversible, neurotrophin-dependent state.Oncogene · 2001Article
- Article
- The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease.The American journal of pathology · 2000Article
- Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Telomerase regulation during entry into the cell cycle in normal human T cells.Molecular biology of the cell · 1996Article
- The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells.Molecular and cellular biology · 1996Article
- Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells.The Journal of cell biology · 1995Article
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2 authors at 1 institution in 1 country.
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Abstract
In the absence of serum, nerve growth factor (NGF) promotes the survival and differentiation of the PC12 pheochromocytoma cell line. In the presence of serum, NGF acts primarily as a differentiation factor and negative regulator of cell cycling. To investigate NGF control of cell cycling, we have analyzed the regulation of cyclin dependent kinases during PC12 cell differentiation. NGF treatment leads to a reduction in the steady-state protein levels of p33cdk2 and p34cdc2, two key regulators of cell cycle progression. The decrease in p33cdk2 and p34cdc2 coincides with a decrease in the enzymatic activity of cyclinA-p34cdc2, cyclinB-p34cdc2, cyclinE-p33cdk2, and cyclinA-p33cdk2 kinases. The decline in p33cdk2 and p34cdc2 kinase activity in response to NGF is accelerated in cells that over-express the p140trk NGF receptor, suggesting that the timing of the down- regulation is dependent on the level of p140trk and the strength of the NGF signal. The level of cyclin A, a regulatory subunit of p33cdk2 and p34cdc2, is relatively constant during PC12 differentiation. Nevertheless, the DNA binding activity of the cyclinA-associated transcription factor E2F/DP decreases. Thus, NGF down-regulates the activity of cyclin dependent kinases and cyclin-transcription factor complexes during PC12 differentiation.
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