ArticleProceedings of the National Academy of Sciences of the United States of America1995
Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats.The Journal of comparative neurology · 2016Article
- High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning.Experimental neurobiology · 2012Article
- Molecular mechanisms underlying memory consolidation of taste information in the cortex.Frontiers in behavioral neuroscience · 2011Article
- The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making.Brain structure & function · 2010Review
- Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.Nature medicine · 2008Article
- Facilitation of taste memory acquisition by experiencing previous novel taste is protein-synthesis dependent.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: a FOS and behavioral analysis.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
- Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task.Neurochemical research · 2007Article
- Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Redundant basal forebrain modulation in taste aversion memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The fickle mutation of a cytoplasmic tyrosine kinase effects sensitization but not dishabituation in Drosophila melanogaster.Journal of neurogeneticsArticle
- Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein tyrosine phosphorylation is a major signal transduction pathway involved in cellular metabolism, growth, and differentiation. Recent data indicate that tyrosine phosphorylation also plays a role in neuronal plasticity. We are using conditioned taste aversion, a fast and robust associative learning paradigm subserved among other brain areas by the insular cortex, to investigate molecular correlates of learning and memory in the rat cortex. In conditioned taste aversion, rats learn to associate a novel taste (e.g., saccharin) with delayed poisoning (e.g., by LiCl injection). Here we report that after conditioned taste aversion training, there is a rapid and marked increase in tyrosine phosphorylation of a set of proteins in the insular cortex but not in other brain areas. A major protein so modulated, of 180 kDa, is abundant in a membrane fraction and remains modulated for more than an hour after training. Exposure of the rats to the novel taste alone results in only a small modulation of the aforementioned proteins whereas administration of the malaise-inducing agent per se has no effect. To the best of our knowledge, this is the first demonstration of modulation of protein tyrosine phosphorylation in the brain after a behavioral experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.