ArticleProceedings of the National Academy of Sciences of the United States of America1995
The canine betaine gamma-amino-n-butyric acid transporter gene: diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 60 citations in OpenAlex.
- A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.Frontiers in physiology · 2023Review
- Analysis of Host Jejunum Transcriptome and Associated Microbial Community Structure Variation in Young Calves with Feed-Induced Acidosis.Metabolites · 2021Article
- The betaine/GABA transporter and betaine: roles in brain, kidney, and liver.Frontiers in physiology · 2014Review
- Downregulation of the creatine transporter SLC6A8 by JAK2.The Journal of membrane biology · 2012Article
- Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT.Pflugers Archiv : European journal of physiology · 2006Article
- Induction of betaine-gamma-aminobutyric acid transport activity in porcine chondrocytes exposed to hypertonicity.The Journal of physiology · 1999Article
- Structure and alternative promoters of the mouse glutamic acid decarboxylase 67 gene.The Biochemical journal · 1997Article
- Characterization of the osmotic response element of the human aldose reductase gene promoter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Na+/myo-inositol transport is regulated by basolateral tonicity in Madin-Darby canine kidney cells.The Journal of clinical investigation · 1996Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The Na(+)- and Cl(-)-coupled betaine transporter, designated BGT1, a member of the neurotransmitter transporter gene family, is responsible for accumulation of betaine in hypertonic Madin-Darby canine kidney (MDCK) cells and presumably in the hypertonic renal medulla. The canine gene for the betaine gamma-amino-n-butyric acid transporter has been cloned and analyzed. The gene extends over 28 kb and consists of 18 exons. The 5' end of the gene has three alternative first exons (1A, 1B, and 1C+D). Analysis of BGT1 mRNA revealed that there is considerable divergence in the 5' untranslated sequence resulting from three different 5' end motifs (A, B, and C) followed by an alternative motif (D) as well as two internal acceptor sites for splicing. Eight kinds of BGT1 mRNA were classified into three types (A, B, and C) according to the 5' end sequence. Northern blot analysis using probes specific for the A, B, or C motif revealed that hypertonicity induces all three types in MDCK cells. Reverse transcription and polymerase chain reaction showed that each type was expressed in a tissue-specific manner. Primer extension and/or RNase protection assays as well as transfection assays into MDCK cells demonstrated that exons 1A, 1B, and 1C+D have independent transcription initiation sites under control of independent promoters. Diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner.
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