ArticleNucleic acids research1995
Regulation of fibronectin expression in rat regenerating liver.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Article
- Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice.Hepatology (Baltimore, Md.) · 2012Article
- Fibronectin: functional character and role in alcoholic liver disease.World journal of gastroenterology · 2011Review
- New insights into form and function of fibronectin splice variants.The Journal of pathology · 2008Review
- RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon.Molecular and cellular biology · 2004Article
- Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing.The EMBO journal · 2001Article
- Host microvasculature influence on tumor vascular morphology and endothelial gene expression.The American journal of pathology · 1998Article
- Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats.Molecular and cellular biology · 1998Article
- HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibronectin (FN) expression displays a complex regulation that results in precisely defined isoform patterns during different developmental stages, ageing and injury. The qualitative and quantitative changes that are observed derive from modulation of the rate of transcription of the single FN pre-mRNA and its specific differential processing in the EIIIA, EIIIB and V regions of rat FN. The liver is the major source of plasma FN which is characterised by the absence of the EIIIA and EIIIB exons. Here we show that in the rat regenerating liver there is a significant reprogramming of the splicing machinery that results in the synthesis by the liver of up to 17% of EIIIA+ FN linked with all the three V forms. On the other hand the EIIIB+ form is totally absent both in normal and regenerating liver. Furthermore there is a variation of the V pattern observed in the regenerating tissue, the V120 form (linked to both EIIIA+ and EIIIA- messengers) increases from 11 to 32%. The quantitative RT-PCR method was used to estimate the FN transcription rate, before and after partial hepatectomy. We have shown a 3-fold increase in FN mRNA in liver that is specifically linked to the regeneration process and not to the surgical stress.
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