ArticleMolecular and cellular biology1995
Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Fluorescent toys 'n' tools lighting the way in fungal research.FEMS microbiology reviews · 2021Article
- A Multimodal Imaging Approach EnablesAntimicrobial agents and chemotherapy · 2018Article
- Bcr1 plays a central role in the regulation of opaque cell filamentation in Candida albicans.Molecular microbiology · 2013Article
- Application of bioluminescence imaging for in vivo monitoring of fungal infections.International journal of microbiology · 2012Article
- Antigenic and phenotypic variations in fungi.Cellular microbiology · 2009Review
- Phenotypic Switching in Fungi.Current fungal infection reports · 2008Article
- Tetracycline-inducible gene expression and gene deletion in Candida albicans.Eukaryotic cell · 2005Article
- Molecular genetic and genomic approaches to the study of medically important fungi.Infection and immunity · 2003Review
- Roles of TUP1 in switching, phase maintenance, and phase-specific gene expression in Candida albicans.Eukaryotic cell · 2002Article
- The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans.Journal of bacteriology · 2001Article
- Differential activation of a Candida albicans virulence gene family during infection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- EFG1 null mutants of Candida albicans switch but cannot express the complete phenotype of white-phase budding cells.Journal of bacteriology · 2000Article
- Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP.Infection and immunity · 2000Article
- Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection.Infection and immunity · 1999Article
- Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator.Infection and immunity · 1999Article
- A MADS box protein consensus binding site is necessary and sufficient for activation of the opaque-phase-specific gene OP4 of Candida albicans.Journal of bacteriology · 1998Article
- Lack of consistent short sequence repeat polymorphisms in genetically homologous colonizing and invasive Candida albicans strains.Journal of bacteriology · 1998Article
- Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.Journal of bacteriology · 1998Article
- Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence.Infection and immunity · 1997Article
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3 authors.
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Abstract
Candida albicans WO-1 switches spontaneously, frequently, and reversibly between a hemispherical white and a flat gray (opaque) colony-forming phenotype. This transition affects a number of morphological and physiological parameters and involves the activation and deactivation of phase-specific genes. The WH11 gene is transcribed in the white but not the opaque phase. A chimeric WH11-firefly luciferase gene containing the 5' upstream region of WH11 was demonstrated to be under phase regulation regardless of the site of integration, and a series of promoter deletion constructs was used to delineate two white-phase-specific transcription activation domains. Gel retardation experiments with the individual distal or proximal domain and white-phase or opaque-phase protein extract demonstrated the formation of one distal white-phase-specific complex and two proximal white-phase-specific complexes. Specific subfragments were tested for their ability to compete with the entire domain in the formation of complexes with white-phase protein extract in order to map the proximal domain sequence involved in white-phase-specific complex formation. Our results indicate that white-phase-specific transcription of WH11 is positively regulated by trans-acting factors interacting with two cis-acting activation sequences in the WH11 promoter.
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