ArticleMolecular and cellular biology1995
Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 160 citations in OpenAlex.
- Wrong place, wrong time: Runt-related transcription factor 2/SATB2 pathway in bone development and carcinogenesis.Journal of carcinogenesis · 2021Review
- Comparative study of the osteogenic potential of mesenchymal stem cells derived from different sources.Journal of clinical and experimental dentistry · 2018Article
- DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.Scientific reports · 2017Article
- A limb-girdle myopathy phenotype of RUNX2 mutation in a patient with cleidocranial dysplasia: a case study and literature review.BMC neurology · 2017Review
- PTH Signaling and Epigenetic Control of Bone Remodeling.Current molecular biology reports · 2016Article
- A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells.PeerJ · 2016Article
- The RUNX complex: reaching beyond haematopoiesis into immunity.Immunology · 2015Review
- Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5.Stem cells international · 2015Article
- Osteoclastogenic potential of peripheral blood mononuclear cells in cleidocranial dysplasia.International journal of medical sciences · 2014Article
- Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production.The Journal of biological chemistry · 2011Article
- Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.Cytokine · 2011Review
- Inducible expression of Runx2 results in multiorgan abnormalities in mice.Journal of cellular biochemistry · 2011Article
- The Role of RUNX2 in Osteosarcoma Oncogenesis.Sarcoma · 2011Article
- Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain.Journal of cellular physiology · 2008Article
- Luteinizing hormone-induced RUNX1 regulates the expression of genes in granulosa cells of rat periovulatory follicles.Molecular endocrinology (Baltimore, Md.) · 2006Article
- Article
- The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.Molecular and cellular biology · 2005Article
- Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography.British journal of cancer · 2005Article
- Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.Oncogene · 2004Review
- Structure and regulated expression of mammalian RUNX genes.Oncogene · 2004Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PEBP2 alpha A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor, PEBP2, which is implicated as a T-cell-specific transcriptional regulator. These two related genes share the evolutionarily conserved region encoding the Runt domain. PEBP2 alpha B is the murine counterpart of human AML1, which is located at the breakpoints of the 8;21 and 3;21 chromosome translocations associated with acute myeloid leukemia. Northern (RNA) blots of various adult mouse tissues revealed that the levels of expression of both genes were most prominent in the thymus. Furthermore, transcripts of PEBP2 alpha A and mouse AML1/PEBP2 alpha B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization. The expression of the genes persisted in peripheral lymph nodes of adult mice. The transcripts were detected in all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations. The results indicated that both genes are expressed in T cells throughout their development, supporting the notion that PEBP2 is a T-cell-specific transcription factor. Transcripts of mouse AML1/PEBP2 alpha B were also detected in day 12 fetal hematopoietic liver and in the bone marrow cells of newborn mice. The implication of mouse AML1/PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis.
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