ArticleMolecular and cellular biology1995
BC1 RNA: transcriptional analysis of a neural cell-specific RNA polymerase III transcript.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Uncovering a mammalian neural-specific poly(A) binding protein with unique properties.Genes & development · 2023Article
- Article
- The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology.International journal of molecular sciences · 2022Review
- RNA Polymerase III Subunit Mutations in Genetic Diseases.Frontiers in molecular biosciences · 2021Review
- Brain Cytoplasmic RNAs in Neurons: From Biosynthesis to Function.Biomolecules · 2020Review
- BC200 (BCYRN1) - The shortest, long, non-coding RNA associated with cancer.Non-coding RNA research · 2018Review
- Brain cytoplasmic RNA 1 suppresses smooth muscle differentiation and vascular development in mice.The Journal of biological chemistry · 2018Article
- BC1 RNA motifs required for dendritic transport in vivo.Scientific reports · 2016Article
- Gene duplication and neofunctionalization: POLR3G and POLR3GL.Genome research · 2014Article
- Contributions of in vitro transcription to the understanding of human RNA polymerase III transcription.Transcription · 2014Review
- Translational control at the synapse: role of RNA regulators.Trends in biochemical sciences · 2013Review
- A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver.Genome research · 2012Article
- Genomic relationship between SINE retrotransposons, Pol III-Pol II transcription, and chromatin organization: the journey from junk to jewel.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
- The evolution and expression of the snaR family of small non-coding RNAs.Nucleic acids research · 2011Article
- Neuronal untranslated BC1 RNA: targeted gene elimination in mice.Molecular and cellular biology · 2003Article
- An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.Molecular and cellular biology · 2003Article
- RNA transport in dendrites: a cis-acting targeting element is contained within neuronal BC1 RNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- BC1 RNA, the transcript from a master gene for ID element amplification, is able to prime its own reverse transcription.Nucleic acids research · 1997Article
- The SRP9/14 subunit of the human signal recognition particle binds to a variety of Alu-like RNAs and with higher affinity than its mouse homolog.Nucleic acids research · 1997Article
- The 3' ends of tRNA-derived short interspersed repetitive elements are derived from the 3' ends of long interspersed repetitive elements.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Rodent BC1 RNA represents the first example of a neural cell-specific RNA polymerase III (Pol III) transcription product. By developing a rat brain in vitro system capable of supporting Pol III-directed transcription, we showed that the rat BC1 RNA intragenic promoter elements, comprising an A box element and a variant B box element, as well as its upstream region, containing octamer-binding consensus sequences and functional TATA and proximal sequence element sites, are necessary for transcription. The BC1 B box, lacking the invariant A residue found in the consensus B boxes of tRNAs, represents a functionally related and possibly distinct promoter element. The transcriptional activity of the BC1 B box element is greatly increased, in both a BC1 RNA and a chimeric tRNA(Leu) gene construct, when the BC1 5' flanking region is present and is appropriately spaced. Moreover, a tRNA consensus B-box sequence can efficiently replace the BC1 B box only if the BC1 upstream region is removed. These interactions, identified only in a homologous in vitro system, between upstream Pol II and intragenic Pol III promoters suggest a mechanism by which the tissue-specific BC1 RNA gene and possibly other Pol III-transcribed genes can be regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.