ArticleMolecular and cellular biology1995
The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 99 citations in OpenAlex.
- HOXA9 transcription factor is a double-edged sword: from development to cancer progression.Cancer metastasis reviews · 2024Review
- HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.Cellular and molecular life sciences : CMLS · 2020Review
- Review
- HOXA10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through HDAC1.Cancer management and research · 2019Article
- Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.Frontiers in oncology · 2018Article
- Is the Epididymis a Series of Organs Placed Side By Side?Biology of reproduction · 2016Review
- Article
- Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling.Biology open · 2012Article
- Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.PloS one · 2011Article
- Regional development of uterine decidualization: molecular signaling by Hoxa-10.Molecular reproduction and development · 2010Review
- Signalling molecules: clues from development of the limb bud for cryptorchidism?Pediatric surgery international · 2007Review
- HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.Molecular and cellular biology · 2007Article
- Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina).Journal of negative results in biomedicine · 2006Article
- A genomic approach to the identification and characterization of HOXA13 functional binding elements.Nucleic acids research · 2005Article
- p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells.Genes & development · 2000Article
- Sequence analysis and tissue specific expression of human HOXA7.Molecular biotechnology · 2000Article
- HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.Molecular and cellular biology · 1999Article
- CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.Molecular and cellular biology · 1999Article
- Deletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families.American journal of human genetics · 1998Article
- A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.Molecular and cellular biology · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox genes of the Abdominal B (AbdB) family constitute a distinct subset of vertebrate Hox genes. Analysis of the murine Hoxa-10 gene, one member of this family, revealed several properties specific to this class. Two transcripts of Hoxa-10, a10-1 and a10-2, encode homeodomain proteins of 55 kDa (399 amino acids) and 16 kDa (96 amino acids), respectively. These proteins have identical homeodomains and C-terminal regions encoded by a common 3' exon but differ significantly in the sizes of their N-terminal regions because of the usage of alternative 5' exons. The 5' exon of the a10-2 form is also present in transcripts of Hoxa-9, the next 3' gene, indicating that splicing can occur between adjacent AbdB Hox genes within a cluster. Both Hoxa-10 transcripts demonstrated identical patterns of expression in the posterior body and proximal limb bud, differentiating them from AbdB morphogenetic and regulatory transcripts and suggesting a role with other AbdB Hox genes in the patterning of these structures. Finally, a binding site selection identified the sequence AA(A/T)TTTTATTAC as the Hoxa-10 homeodomain consensus binding site, with a TTAT core sequence. Preferential recognition of a TTAT core therefore differentiates the AbdB class from Antennapedia (Antp) class gene products which bind a TAAT core. Thus, in vertebrates, structural similarities, coordinate transcriptional regulation, sites of expression, and binding site preferences all serve to distinguish AbdB from Antp Hox genes.
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Registered trials
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