ArticleMolecular and cellular biology1995
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- The Configuration of GRB2 in Protein Interaction and Signal Transduction.Biomolecules · 2024Review
- Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.The EMBO journal · 2021Article
- Review
- Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression.Biomedical reports · 2016Article
- hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.International immunology · 2009Article
- Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.The Journal of biological chemistry · 2008Article
- Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Cellular signalling · 2008Article
- A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation.Blood · 2006Article
- Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Experimental cell research · 2005Article
- Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter.The Biochemical journal · 2005Article
- Article
- Translational regulation by the p210 BCR/ABL oncoprotein.Oncogene · 2004Review
- Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation.British journal of cancer · 2003Article
- Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.Nucleic acids research · 2003Article
- The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.RNA (New York, N.Y.) · 2002Review
- Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length.Molecular and cellular biology · 2002Article
- Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain.Journal of biomolecular NMR · 2002Article
- Article
- Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used the yeast two-hybrid system to isolate proteins that interact with the carboxy-terminal SH3-SH2-SH3 region of Vav. One of the clones encoded heterogeneous nuclear ribonucleoprotein K (hnRNP K), a poly(rC)-specific RNA-binding protein. The interaction between Vav and hnRNP K involves the binding of the most carboxy-terminal SH3 domain of Vav to two proline-rich sequences present in the central region of hnRNP K. Overexpression of Vav in mouse fibroblasts leads to the formation of a stable complex with the endogenous hnRNP K and to the preferential redistribution of this protein to the cytoplasmic fraction. More importantly, Vav and hnRNP K proteins also interact in hematopoietic cells. In addition, Vav associates in vitro with a second 45-kDa poly(rC)-specific RNA-binding protein via its SH3-SH2-SH3 region. These results suggest that Vav plays a role in the regulation of the late steps of RNA biogenesis by modulating the function of poly(rC)-specific ribonucleoproteins.
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