ArticleMolecular and cellular biology1995
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation.Scientific reports · 2019Article
- Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.Journal of neuroinflammation · 2016Article
- Enhanced cytotoxicity from deoxyguanosine-enriched T-oligo in prostate cancer cells.Nucleic acid therapeutics · 2013Article
- p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms.Molecular and cellular biology · 2012Article
- T-oligos inhibit growth and induce apoptosis in human ovarian cancer cells.Oligonucleotides · 2011Article
- The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling.Gene · 2009Article
- Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.Journal of periodontal research · 2008Article
- Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.Stem cells (Dayton, Ohio) · 2008Article
- The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.Molecular biology of the cell · 2008Article
- Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.The EMBO journal · 2005Article
- Adenoviral gene transfer of PDGF downregulates gas gene product PDGFalphaR and prolongs ERK and Akt/PKB activation.American journal of physiology. Cell physiology · 2002Article
- Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.Molecular and cellular biology · 2000Article
- Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.The Biochemical journal · 1997Article
- Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.Molecular and cellular biology · 1996Article
- The platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Rational cancer therapy.Nature medicine · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet-derived growth factor BB (PDGF-BB) is an important extracellular factor for regulating the G0-S phase transition of murine BALB/c-3T3 fibroblasts. We have investigated the expression of the PDGF beta receptor (PDGF beta R) in these cells. We show that the state of growth arrest in G0, resulting from serum deprivation, is associated with increased expression of the PDGF beta R. When the growth-arrested fibroblasts are stimulated to reenter the cell cycle by the mitogenic action of serum or certain specific combinations of growth factors, PDGF beta R mRNA levels and cell surface PDGF-BB-binding sites are markedly downregualted. Oncogene-transformed 3T3 cell lines, which fail to undergo growth arrest following prolonged serum deprivation, express constitutively low levels of the PDGF beta R mRNA and possess greatly reduced numbers of cell surface PDGF receptors, as determined by PDGF-BB binding and Western blotting (immunoblotting). Nuclear runoff assays indicate the mechanism of repression of PDGF beta R expression to be, at least in large part, transcriptional. These data indicate that expression of the PDGF beta R is regulated in a growth state-dependent manner in fibroblasts and suggest that this may provide a means by which cells can modulate their responsiveness to the actions of PDGF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.