ArticleMolecular and cellular biology1995
Binding of NCK to SOS and activation of ras-dependent gene expression.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 94 citations in OpenAlex.
- Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily.Cells · 2024Article
- Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.Frontiers in cell and developmental biology · 2021Review
- Nck1 promotes the progression of ovarian carcinoma by enhancing the PI3K/AKT/p70S6K signaling.Human cell · 2020Article
- VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways.NPJ systems biology and applications · 2018Article
- GWAS analysis of QTL for enteric septicemia of catfish and their involved genes suggest evolutionary conservation of a molecular mechanism of disease resistance.Molecular genetics and genomics : MGG · 2017Article
- Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations.Cancer research · 2014Article
- Observations on the effects of Suppressor of Cytokine Signaling 7 (SOCS7) knockdown in breast cancer cells: their in vitro response to Insulin Like Growth Factor I (IGF-I).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- The role of suppressors of cytokine signalling in human neoplasms.Molecular biology international · 2014Review
- Cancer-associated missense mutations of caspase-8 activate nuclear factor-κB signaling.Cancer science · 2013Article
- Roles of EphA2 in Development and Disease.Genes · 2013Article
- Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.Clinical and experimental immunology · 2012Article
- Studies of novel interactions between Nck and VAV SH3 domains.Communicative & integrative biology · 2011Article
- Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.Biochemistry · 2010Article
- Nck adapter proteins: functional versatility in T cells.Cell communication and signaling : CCS · 2009Article
- Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis.Genetics · 2001Article
- Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.Molecular biology of the cell · 2000Article
- The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization.Genes & development · 2000Article
- Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation.Molecular and cellular biology · 2000Article
- Cas mediates transcriptional activation of the serum response element by Src.Molecular and cellular biology · 1999Article
- Angiotensin II stimulates serine phosphorylation of the adaptor protein Nck: physical association with the serine/threonine kinases Pak1 and casein kinase I.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
NCK, an SH2- and SH3 domain-containing protein, becomes phosphorylated and associated with tyrosine kinase receptors upon growth factor stimulation. The sequence of NCK suggests that NCK functions as a linker between receptors and a downstream signaling molecule. To determine if NCK can mediate growth factor-stimulated responses, we measured the ability of NCK to activate the fos promoter. We found that in NIH 3T3 cells, NCK strongly activates this promoter. The effect of NCK on the fos promoter is enhanced by c-ras and blocked by dominant negative ras. We also found that NCK binds directly to the guanine nucleotide exchange factor SOS. This interaction is mediated by the SH3 domains of NCK. These findings suggest that NCK can regulate p21ras-dependent gene transcription through interaction with SOS protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.