ArticleMolecular & general genetics : MGG1995
Suppressors of thermosensitive mutations in the DNA polymerase delta gene of Saccharomyces cerevisiae.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- POLD3 as Controller of Replicative DNA Repair.International journal of molecular sciences · 2024Review
- Article
- Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant.Scientific reports · 2017Article
- DNA replication error-induced extinction of diploid yeast.Genetics · 2014Article
- Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mutator suppression and escape from replication error-induced extinction in yeast.PLoS genetics · 2011Article
- The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions.DNA repair · 2010Article
- Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis.BMC molecular biology · 2009Article
- Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae.Current genetics · 2009Article
- The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.Nucleic acids research · 2004Article
- Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.Current genetics · 2003Article
- The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.The Journal of cell biology · 1998Article
- Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase.Genetics · 1998Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA polymerases (Pol) alpha, delta and epsilon are necessary for replication of nuclear DNA. Pol delta interacts permanently or transiently with numerous accessory proteins whose identification may shed light on the function(s) of Pol delta. In vitro mutagenesis was used to induce thermosensitive (ts) mutations in the DNA polymerase delta gene (POL3). We have attempted to clone two recessive extragenic suppressors of such ts mutants (sdp1 for mutation pol3-14 and sdp5-1 for mutation pol3-11) by transforming thermoresistant haploid strains pol3-14 sdp1 and pol3-11 sdp5-1 with wild-type genomic libraries in singlecopy or multicopy vectors. None of the thermosensitive transformants so obtained was identified as being sdp1 or sdp5-1. Instead, three genes were cloned whose products interfere with the activity of suppressors. One of them is the type 1 protein phosphatase gene, DIS2. Another is a novel gene, ASM4, whose gene product is rich in asparagine and glutamine residues.
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