ArticleThe Journal of clinical investigation1995
Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin.The Journal of investigative dermatology · 2010Article
- Neuregulin3 alters cell fate in the epidermis and mammary gland.BMC developmental biology · 2007Article
- Roles for neuregulins in human cancer.Clinical & experimental metastasis · 2004Review
- Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.Oncogene · 2003Article
- Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors.Oncogene · 2000Article
- Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells.Molecular biology of the cell · 1998Article
- Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.The Journal of clinical investigation · 1997Article
- Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus.Molecular and cellular biology · 1997Article
- ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling.Journal of mammary gland biology and neoplasia · 1997Review
- Interaction between the insulin-like growth factor family and the integrin receptor family in tissue repair processes. Evidence in a rabbit ear dermal ulcer model.The Journal of clinical investigation · 1996Article
- Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor.The American journal of pathology · 1995Article
- The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.Molecular and cellular biology · 1995Article
- Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neu differentiation factor (NDF) is a 44-kD glycoprotein which was isolated from ras-transformed rat fibroblasts and indirectly induces tyrosine phosphorylation of the HER-2/neu receptor via binding to either the HER-3 or HER-4 receptor. NDF contains a receptor binding epidermal growth factor (EGF)-like domain and is a member of the EGF family. There are multiple different isoforms of NDF which arise by alternative splicing of a single gene. To date, in vivo biologic activities have not been demonstrated for any NDF isoform. Since NDF, HER-2/neu, and HER-3 are present in skin, and other EGF family members can influence wound keratinocytes in vivo, we investigated whether NDF would stimulate epidermal migration and proliferation in a rabbit ear model of excisional wound repair. In this model, recombinant human NDF-alpha 2 (rhNDF-alpha 2), applied once at the time of wounding, induced a highly significant increase in both epidermal migration and epidermal thickness at doses ranging from 4 to 40 micrograms/cm2. In contrast, rhNDF-alpha 1, rhNDF-beta 1, and rhNDF-beta 2 had no apparent biologic effects in this model. rhNDF-alpha 2 also induced increased neoepidermal expression of alpha 5 and alpha 6 integrins, two of the earliest integrins to appear during epidermal migration. In addition, rhNDF-alpha 2-treated wounds exhibited increased neoepidermal expression of cytokeratin 10 and filaggrin, both epidermal differentiation markers. NDF alpha isoforms were expressed in dermal fibroblasts of wounded and unwounded skin, while both HER-2/neu and HER-3 were expressed in unwounded epidermis and dermal adnexa. In wounds, HER-2/neu expression was markedly decreased in the wound neoepidermis while neoepidermal HER-3 expression was markedly upregulated. Taken together, these results suggest that endogenous NDF-alpha 2 may function as a paracrine mediator directing initial epidermal migration during cutaneous tissue repair.
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