Trial reportThe Journal of clinical investigation1995
Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus.
Trial report in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 211 citations in OpenAlex.
- Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials.Clinical nutrition (Edinburgh, Scotland) · 2011Pooled it
- Identification of Potential Plant-Derived Pancreatic Beta-Cell-Directed Agents Using New Custom-Designed Screening Method:Molecules (Basel, Switzerland) · 2023Review
- Partners in diabetes epidemic: A global perspective.World journal of diabetes · 2023Review
- Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control.Biomedicines · 2023Review
- Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes.Cardiovascular research · 2023Article
- iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion.Stem cell research & therapy · 2022Article
- Insulin sensitivity variations in apparently healthy Arab male subjects: correlation with insulin and C peptide.BMJ open diabetes research & care · 2021Article
- No Association Between a Genetic Variant ofIndian journal of clinical biochemistry : IJCB · 2021Article
- Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes.Frontiers in endocrinology · 2021Article
- Roux-en-Y gastric bypass surgery improves hepatic glucose metabolism and reduces plasma kisspeptin levels in morbidly obese patients with type 2 diabetes.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-Journal of diabetes research · 2019Article
- Circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) levels are associated with hyperglycemia and β cell dysfunction in a Chinese population.Scientific reports · 2017Article
- Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.Diabetologia · 2015Article
- Influence of cardiorespiratory fitness on PPARG mRNA expression using monozygotic twin case control.Journal of diabetes research · 2015Article
- Twins and endocrinology.Indian journal of endocrinology and metabolism · 2014Review
- Prkar1a in the regulation of insulin secretion.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes.PloS one · 2012Article
- Snapin mediates incretin action and augments glucose-dependent insulin secretion.Cell metabolism · 2011Article
- Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit.Nature chemical biology · 2011Article
- T2DM: Why Epigenetics?Journal of nutrition and metabolism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
12 identical twin pairs discordant for non-insulin-dependent diabetes mellitus (NIDDM) were studied for insulin sensitivity (euglycemic insulin clamp, 40 mU/m2 per min), hepatic glucose production (HGP, [3-3H]glucose infusion), and insulin secretion (oral glucose tolerance test and hyperglycemic [12 mM] clamp, including glucagon administration). Five of the nondiabetic twins had normal and seven had impaired glucose tolerance. 13 matched, healthy subjects without a family history of diabetes were included as control subjects. The NIDDM twins were more obese compared with their non-diabetic co-twins. The nondiabetic twins were insulin resistant and had a delayed insulin and C-peptide response during oral glucose tolerance tests compared with controls. Furthermore, the nondiabetic twins had a decreased first-phase insulin response and a decreased maximal insulin secretion capacity during hyperglycemic clamping and intravenous glucagon administration. Nondiabetic twins and controls had similar rates of HGP. Compared with both nondiabetic twins and controls, the NIDDM twins had an elevated basal rate of HGP, a further decreased insulin sensitivity, and a further impaired insulin secretion pattern as determined by all tests. In conclusion, defects of both in vivo insulin secretion and insulin action are present in non- and possibly prediabetic twins who possess the necessary NIDDM susceptibility genes. However, all defects of both insulin secretion and glucose metabolism are expressed quantitatively more severely in their identical co-twins with overt NIDDM.
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