ArticleThe Journal of clinical investigation1995
Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 132 citations in OpenAlex.
- Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship.PloS one · 2017Article
- Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a review.Journal of lipid research · 2014Review
- Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry.Biochemistry · 2014Article
- Article
- Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy.Journal of lipid research · 2013Article
- Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.PloS one · 2012Article
- Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.PloS one · 2011Article
- Apolipoprotein E: from lipid transport to neurobiology.Progress in lipid research · 2011Review
- Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Biological chemistry · 2010Review
- The relative atherogenicity of VLDL and LDL is dependent on the topographic site.Journal of lipid research · 2010Article
- Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.Biochemistry · 2007Article
- Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.The Biochemical journal · 2007Article
- Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner.The Journal of biological chemistry · 2007Article
- The key role of apolipoprotein E in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Apolipoprotein E-induced cell signaling in the vessel wall.Reviews in endocrine & metabolic disorders · 2004Review
- Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice.The American journal of pathology · 2000Article
- High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis.Current atherosclerosis reports · 2000Review
- A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E.Gene therapy · 1999Article
- Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.The Journal of clinical investigation · 1999Article
- Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apolipoprotein E (apoE) plays a crucial role in lipoprotein metabolism both in plasma and in peripheral tissues. To test whether apoE in the vascular wall has a direct and local effect on atherogenesis, we established transgenic mice expressing human apoE under control of H2 Ld promoter. Studies on mRNA levels and immunohistochemistry demonstrated that this line was characterized by high expression of human apoE in the arterial wall while its expression was relatively low in other tissues as compared with the respective endogenous expression of mouse apoE. They showed no difference in plasma cholesterol levels and lipoprotein profile from controls when fed both normal and atherogenic diets. However, after 24 wk of an atherogenic diet, the formation of fatty streak lesions in proximal aorta was markedly inhibited in transgenic mice as compared with controls. Both lesion area and esterified cholesterol content were < 30% of those in controls. In a tissue cholesterol labeling study with 3H-cholesterol, the specific activity of aorta cholesterol was much less in transgenic mice, suggesting that apoE enhances cholesterol efflux from the aortic wall into plasma. Thus, apoE has anti-atherogenic action which is mediated via enhancing reverse cholesterol transport from arterial wall.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.