Evidence map›Paper›PMID 7860699›Full record

ArticleJournal of muscle research and cell motility1994

Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit.

J I Rushbrook, C Weiss, K Ko, M H Feuerman, S Carleton, A Ing, J Jacoby

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 56 citations in OpenAlex.

  1. Research into the physiology of myosins - a personal odyssey.European journal of translational myology · 2025
    Article
  2. Extreme Tolerance of Extraocular Muscles to Diseases and Aging: Why and How?International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

J I RushbrookNew York University Medical Center, Department of Ophthalmology, N.Y. 10016.
C Weiss
K Ko
M H Feuerman
S Carleton
A Ing
J Jacoby
SUNY Downstate Health Sciences University · USColumbia University Irving Medical Center · USNew York University · US

Funding

CORE GRANT FOR VISION RESEARCHP30EY001842 · NEI · NEW YORK UNIVERSITY · PI WITKOVSKY, PAUL · 1985 to 1991
–
EXTRAOCULAR MUSCLE: FIBER PROPERTIES &DEVELOPMENTR01EY006232 · NEI · NEW YORK UNIVERSITY · PI JACOBY, JEAN · 1989 to 1993
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EXTRAOCULAR MUSCLE: FIBER PROPERTIES AND DEVELOPMENTR23EY006232 · NEI · NEW YORK UNIVERSITY · PI JACOBY, JEAN · 1986 to 1988
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NEI NIH HHS EY 01842NEI NIH HHS EY 06232
6 · The paper itself

Abstract

Extraocular muscles contain both fast-twitch and multiply-innervated, tonic-contracting fibres. In rat, these fibres collectively express numerous myosin heavy chain isoforms including fast-type embryonic and neonatal, adult slow twitch type I and fast twitch type II, and a fast isoform unique to extraocular muscle. Immunocytochemical and Western blotting results are presented which suggest that, in rabbit, an additional species, the alpha-cardiac myosin heavy chain, is present. The immunoreactive species is found in all rabbit extraocular muscles and in the extraocular muscles is expressed in almost all fibres which do not contain a fast myosin heavy chain. Positive identification of this isoform as the alpha-cardiac myosin heavy chain was obtained by sequencing a cloned PCR product derived from extraocular muscle mRNA unique to the 3'-end of rabbit alpha-cardiac myosin heavy chain mRNA. This is the first unequivocal demonstration of alpha-cardiac myosin heavy chain expression in extraocular muscle.

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalBase SequenceFemaleImmunoenzyme TechniquesMolecular Sequence DataMusclesMyocardiumMyosinsOculomotor MusclesPolymerase Chain ReactionRabbitsRNA, MessengerSequence AlignmentSequence Homology, Nucleic AcidAntibodies, MonoclonalMyosinsRNA, Messenger

Identifiers

PMID7860699
OpenAlexW2064268092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.