ArticleBritish journal of pharmacology1994
Pharmacological profile of the ATP-mediated increase in L-type calcium current amplitude and activation of a non-specific cationic current in rat ventricular cells.
Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cardiac purinergic signalling in health and disease.Purinergic signalling · 2015Review
- Cardiac P2X purinergic receptors as a new pathway for increasing Na⁺ entry in cardiac myocytes.American journal of physiology. Heart and circulatory physiology · 2014Article
- The therapeutic effect of 2-cyclohexylthio-AMP in heart failure.Journal of cardiovascular pharmacology · 2013Article
- Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.Journal of medicinal chemistry · 2010Article
- Could early ischemic arrhythmia triggered by purinergic activation of the transient receptor potential channels be prevented by creatine?Experimental and clinical cardiology · 2010Article
- Interaction of P2 purinergic receptors with cellular macromolecules.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- P2 receptors in cardiovascular regulation and disease.Purinergic signalling · 2008Article
- P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.American journal of physiology. Heart and circulatory physiology · 2007Article
- Functions of neuronal P2Y receptors.Pflugers Archiv : European journal of physiology · 2006Review
- Regulation of neuronal ion channels via P2Y receptors.Purinergic signalling · 2004Article
- Regulation of L-type Ca2+ channels in the heart: overview of recent advances.Molecular and cellular biochemistry · 2003Review
- P2 receptor subtypes in the cardiovascular system.The Biochemical journal · 1998Review
- Modulation by extracellular ATP of L-type calcium channels in guinea-pig single sinoatrial nodal cell.British journal of pharmacology · 1996Article
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Authors and funding
2 authors.
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Abstract
1. The pharmacological profile of the ATP-induced increase in ICa amplitude and of ATP activation of a non-specific cationic current, IATP, was investigated in rat ventricular cells. 2. The EC50 values for ICa increase and IATP activation were 0.36 microM and 0.76 microM respectively. Suramin (10 microM) and cibacron blue (1 microM) competitively antagonized both effects of ATP. 3. The rank order of efficacy and potency of ATP analogues in increasing ICa amplitude was 2-methylthio-ATP approximately ATP approximately ATP gamma S. The derivatives alpha,beta-methylene-ATP, beta,gamma-methylene-ATP and beta,gamma-imido-ATP up to 500 microM had no significant effects. 4. The rank order of efficacy of ATP analogues in activating a non-specific cationic current, IATP, was 2-methylthio-ATP > ATP >> ATP gamma S. The rank order of potency was 2-methylthio-ATP approximately ATP. The EC50 of ATP gamma S could not be determined owing to its very low efficacy. 5. The ATP analogues alpha,beta-methylene-ATP, beta,gamma-methylene-ATP and beta,gamma-imido-ATP at 500 microM did not activate IATP but acted as antagonists of activation of IATP by ATP. 6. The results suggest that the increase in ICa amplitude induced by external ATP is due to activation of P2Y-purinoceptors. 7. The mechanism of IATP activation remains to be determined before the receptor subtype involved can be deduced.
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