ArticleBiophysical journal1994
Membrane stress increases cation permeability in red cells.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis.Nature physics · 2024Article
- Significance of two transmembrane ion gradients for human erythrocyte volume stabilization.PloS one · 2022Article
- Disorders of erythrocyte hydration.Blood · 2017Review
- Piezo1 regulates mechanotransductive release of ATP from human RBCs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Piezo proteins: regulators of mechanosensation and other cellular processes.The Journal of biological chemistry · 2014Review
- Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.Blood · 2012Article
- Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen.Blood · 2012Article
- Article
- Local membrane deformations activate Ca2+-dependent K+ and anionic currents in intact human red blood cells.PloS one · 2010Article
- Role of band 3 in regulating metabolic flux of red blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Red blood cell membrane fluctuations and shape controlled by ATP-induced cytoskeletal defects.Biophysical journal · 2005Article
- Coupled multi-component systems: A simple membrane model.Journal of biological physics · 2002Article
- Deformability and stability of erythrocytes in high-frequency electric fields down to subzero temperatures.Biophysical journal · 1997Article
- The leukocyte response to fluid stress.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The human red cell is known to increase its cation permeability when deformed by mechanical forces. Light-scattering measurements were used to quantitate the cell deformation, as ellipticity under shear. Permeability to sodium and potassium was not proportional to the cell deformation. An ellipticity of 0.75 was required to increase the permeability of the membrane to cations, and flux thereafter increased rapidly as the limits of cell extension were reached. Induction of membrane curvature by chemical agents also did not increase cation permeability. These results indicate that membrane deformation per se does not increase permeability, and that membrane tension is the effector for increased cation permeability. This may be relevant to some cation permeabilities observed by patch clamping.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.