ArticleBritish heart journal1994
Influence of increased adrenergic activity and magnesium depletion on cardiac rhythm in alcohol withdrawal.
Article in British heart journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review.Nutrients · 2021Pooled it
- Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities Study).The American journal of cardiology · 2014Trial
- Alcohol Consumption Is Associated With Postablation Recurrence but Not Changes in Atrial Substrate in Patients With Atrial Fibrillation: Insight from a High-Density Mapping Study.Journal of the American Heart Association · 2022Article
- The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?Cardiology in the young · 2017Article
- Torsades de Pointes in Severe Alcohol Withdrawal and Cirrhosis: Implications for Risk Stratification and Management.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2017Article
- Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.Journal of biomedical science · 2016Article
- Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation.Journal of the American Heart Association · 2016Article
- [Alcohol and arrhythmias].Herz · 2016Review
- How Does Alcohol Intake Relate to the Risk of Atrial Fibrillation?Journal of atrial fibrillation · 2012Review
- Article
- Methylmalonic acid--an endogenous toxin?Cellular and molecular life sciences : CMLS · 2005Review
- Prevalence of and risk factors for atrial fibrillation in Korean adults older than 40 years.Journal of Korean medical science · 2005Article
- Managing alcohol withdrawal in the elderly.Drugs & aging · 1999Review
- The Estimated Risk of Atrial Fibrillation Related to Alcohol Consumption.Journal of atrial fibrillationReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the prevalence of arrhythmias in alcoholic men during detoxification and its relation to neuroendocrine activation and electrolyte disturbances.
designConsecutive case-control study.
settingPrimary and secondary care, detoxification ward. PATIENTS AND CONTROLS: 19 otherwise healthy alcoholic men (DSM-III-R) with withdrawal symptoms necessitating detoxification in hospital. 19 age matched, healthy non-alcoholic men as controls for Holter recordings.
interventionsTreatment with chlomethiazole; additional treatment with carbamazepine in patients with previous seizures.
main outcome measuresComputer based analyses of mean heart rate and arrhythmias from 24 hour Holter recordings, 24 hour urinary excretion of adrenaline and noradrenaline, magnesium retention measured by means of intravenous loading test, and serum concentrations of electrolytes.
resultsThe 24 hour mean heart rate was higher in the alcoholic men (97.4 beats/minute, 95% confidence interval (CI) 91.2 to 103.6) than in the controls (69.6 beats/minute, 95% CI 65.4 to 73.8, P < 0.001). However, there was no difference in diurnal heart rate variation. The prevalence of premature supraventricular depolarisations was lower in the alcoholic men (P < 0.05). Neither atrial fibrillation nor malignant ventricular arrhythmias occurred. The sinus tachycardia in the alcoholic men correlated with the concomitant urinary excretion of catecholamines (P < 0.05). The mean serum magnesium concentration was 0.78 mmol/l (95% CI 0.73 to 0.83) in the alcoholic men and 0.83 mmol/l (95% CI 0.81 to 0.85) in a reference population of 55 men aged 40. Magnesium depletion (defined as magnesium retention > 30%) was detected in 10 alcoholic men (53%). Three alcoholic men had serum potassium concentrations < or = 3.3 mmol/l on admission.
conclusionIncreased adrenergic activity, magnesium depletion, and hypokalaemia are often seen after heavy drinking, but in alcoholic men without clinical heart disease these changes were not accompanied by arrhythmias other than sinus tachycardia during detoxification in hospital.
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