ArticleThe American journal of pathology1995
Study of the immunohistochemistry and T cell clonality of enteropathy-associated T cell lymphoma.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 173 citations in OpenAlex.
- Extranodal T- and NK-cell lymphomas.Virchows Archiv : an international journal of pathology · 2023Review
- Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma.Cancers · 2022Review
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- Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming.The Journal of clinical investigation · 2021Article
- Brentuximab Vedotin in the Treatment of Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma.Current hematologic malignancy reports · 2020Review
- Pathogenesis of Enteropathy-Associated T Cell Lymphoma.Current hematologic malignancy reports · 2018Review
- Brentuximab vedotin: clinical updates and practical guidance.Blood research · 2017Review
- Recent advances in understanding and managing T-cell lymphoma.F1000Research · 2017Review
- CD1d-restricted peripheral T cell lymphoma in mice and humans.The Journal of experimental medicine · 2016Article
- Supratentorial metastatic enteropathy-associated T-cell lymphoma: A case report and literature review.Surgical neurology international · 2012Article
- Enteropathy-associated T-cell lymphoma: epidemiology, clinical features, and current treatment strategies.Current hematologic malignancy reports · 2011Review
- Refractory celiac disease.Current gastroenterology reports · 2007Review
- Article
- Successful treatment of enteropathy-associated T cell lymphoma with autologous stem cell transplant.Digestive diseases and sciences · 2006Article
- A rare case of enteropathy-associated T-cell lymphoma presenting as acute renal failure.World journal of gastroenterology · 2006Article
- Article
- First steps in unraveling the genotype of enteropathy-type T-cell lymphoma.The American journal of pathology · 2002Article
- Peripheral T-cell lymphoma.Current oncology reports · 2002Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specimens from 23 patients with enteropathy-associated T cell lymphoma were studied by immunohistochemistry after antigen retrieval. Specimens from 14 of these patients were investigated for the presence of clonal T cell gene rearrangements in both the tumor and the adjacent enteropathic intestine by the polymerase chain reaction. Primers for T cell receptor beta and gamma genes were used in a combination that permits the identification of approximately 90% of T cell receptor rearrangements. Clonal rearrangements of the T cell receptor were found in 13 of the 14 tumors studied. Specimens of enteropathic bowel resected with the tumor, but showing no morphological or immunohistochemical evidence of tumor involvement, showed clonal T cell receptor gene rearrangements in 11 cases. In 10 of these, the amplified DNA was of the same molecular weight in the enteropathic bowel as in the corresponding tumor. In 2 cases, sequencing the polymerase chain reaction product showed identical T cell receptor gene rearrangements in the tumor and in the adjacent intestine. Uniform staining for p53 was seen in 22 of the 23 tumors. In 9 of 19 cases studied, collections of small lymphocytes in the enteropathic bowel expressed p53. In all but one of these specimens, a clonal rearrangement of the T cell receptor genes was identified. We interpret these findings as support for the concept that enteropathy-associated T cell lymphoma arises on a background of gluten-sensitive enteropathy with evolution of neoplastic T cell clones from the reactive T cell population present in the enteropathic bowel.
Indexed as
Identifiers
7856760PMC1869840W98607795What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.