ArticlePsychopharmacology1994
Bilateral intra-accumbens self-administration of d-amphetamine: antagonism with intra-accumbens SCH-23390 and sulpiride.
Article in Psychopharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Neurobiology of reward-related learning.Neuroscience and biobehavioral reviews · 2021Review
- Buprenorphine prevents stress-induced blunting of nucleus accumbens dopamine response and approach behavior to food reward in mice.Neurobiology of stress · 2019Article
- Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion.Psychopharmacology · 2017Article
- Article
- Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?Frontiers in cellular neuroscience · 2016Review
- Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats.Neurotoxicity research · 2015Article
- On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.Psychopharmacology · 2015Article
- Dopamine decreases NMDA currents in the oval bed nucleus of the stria terminalis of cocaine self-administering rats.Progress in neuro-psychopharmacology & biological psychiatry · 2014Article
- The medial preoptic area modulates cocaine-induced activity in female rats.Behavioral neuroscience · 2013Article
- Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings.Journal of neurodevelopmental disorders · 2012Article
- Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell.Pharmacology, biochemistry, and behavior · 2011Article
- Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates methamphetamine intra-accumbens self-administration.Neuroscience letters · 2011Article
- Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity.Alcoholism, clinical and experimental research · 2009Article
- Conditioned cues and the expression of stimulant sensitization in animals and humans.Neuropharmacology · 2009Review
- Differences in performance between Sprague-Dawley and Fischer 344 rats in positive reinforcement tasks.Pharmacology, biochemistry, and behavior · 2008Article
- Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective.Brain research reviews · 2007Review
- Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.Brain research reviews · 2007Review
- Forebrain substrates of reward and motivation.The Journal of comparative neurology · 2005Review
- The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of d-amphetamine to support a selective bilateral intra-accumbens self-administration response was examined. Bilateral intra-accumbens infusions of d-amphetamine were made contingent upon the acquisition of a lever-pressing response. Two identical levers were available within the operant chamber. Depression of the drug lever resulted in the intra-accumbens delivery of 1 microgram d-amphetamine; responses upon the second, control lever were recorded but had no programmed consequences. Animals were not 'primed' with non-contingent infusions of d-amphetamine at any time during these experiments. Nonetheless, animals readily acquired a selective response upon the drug lever. Removal of the d-amphetamine moiety from the infusate resulted in a large decline in responding, and the abolition of the selectivity of the response for the drug lever. Adulteration of the infusate with either the D1 dopamine receptor antagonist SCH-23390 or the D2 dopamine receptor antagonist sulpiride enhanced the rate of response selectively upon the drug lever. Reductions in the dose of d-amphetamine also increased the rate of response. The effect of co-adulteration of the infusate with both SCH-23390 and sulpiride together was purely additive. The implications of these data for the methodology of intracranial drug self-administration, and the relationship between D1 and D2 dopamine receptors within the nucleus accumbens are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.