ReviewMicrobiological reviews1994
Chemostat cultivation as a tool for studies on sugar transport in yeasts.
Review in Microbiological reviews, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Being an editor: then and now.Applied and environmental microbiology · 2026Article
- Continuous cultivation of the lithoautotrophic nitrate-reducing Fe(II)-oxidizing culture KS in a chemostat bioreactor.Environmental microbiology reports · 2023Article
- Quantitative Physiology and Proteome Adaptations of Bifidobacterium breve NRBB57 at Near-Zero Growth Rates.Microbiology spectrum · 2023Article
- Physiological Characterization ofInternational journal of environmental research and public health · 2021Article
- Ratio of Electron Donor to Acceptor Influences Metabolic Specialization and Denitrification Dynamics inFrontiers in microbiology · 2021Article
- Impact of Particle-Size Reduction on the Solubility and Antidiabetic Activity of Extracts of Leaves ofTurkish journal of pharmaceutical sciences · 2019Article
- Privatization of public goods can cause population decline.Nature ecology & evolution · 2019Article
- Fungal Growth in Batch Culture - What We Could Benefit If We Start Looking Closer.Frontiers in microbiology · 2019Article
- Cultivation and Transcriptional Analysis of a CanonicalFrontiers in microbiology · 2019Article
- The Duality of the MAPK Signaling Pathway in the Control of Metabolic Processes and Cellulase Production in Trichoderma reesei.Scientific reports · 2018Article
- Laboratory evolution of a glucose-phosphorylation-deficient, arabinose-fermenting S. cerevisiae strain reveals mutations in GAL2 that enable glucose-insensitive l-arabinose uptake.FEMS yeast research · 2018Article
- When increasing population density can promote the evolution of metabolic cooperation.The ISME journal · 2018Article
- l-Arabinose triggers its own uptake via induction of the arabinose-specific Gal2p transporter in an industrialBiotechnology for biofuels · 2018Article
- Harbouring public good mutants within a pathogen population can increase both fitness and virulence.eLife · 2016Article
- Understanding the Role of the Master Regulator XYR1 in Trichoderma reesei by Global Transcriptional Analysis.Frontiers in microbiology · 2016Article
- A novel process-based model of microbial growth: self-inhibition in Saccharomyces cerevisiae aerobic fed-batch cultures.Microbial cell factories · 2015Article
- Metabolism at evolutionary optimal States.Metabolites · 2015Review
- The complex relationship between microbial growth rate and yield and its implications for ecosystem processes.Frontiers in microbiology · 2015Article
- Regulations of sugar transporters: insights from yeast.Current genetics · 2013Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemostat cultivation enables investigations into the effects of individual environmental parameters on sugar transport in yeasts. Various means are available to manipulate the specific rate of sugar uptake (qs) in sugar-limited chemostat cultures. A straightforward way to manipulate qs is variation of the dilution rate, which, in substrate-limited chemostat cultures, is equal to the specific growth rate. Alternatively, qs can be varied independently of the growth rate by mixed-substrate cultivation or by variation of the biomass yield on sugar. The latter can be achieved, for example, by addition of nonmetabolizable weak acids to the growth medium or by variation of the oxygen supply. Such controlled manipulation of metabolic fluxes cannot be achieved in batch cultures, in which various parameters that are essential for the kinetics of sugar transport cannot be controlled. In sugar-limited chemostat cultures, yeasts adapt their sugar transport systems to cope with the low residual sugar concentrations, which are often in the micromolar range. Under the conditions, yeasts with high-affinity proton symport carriers have a competitive advantage over yeasts that transport sugars via facilitated-diffusion carriers. Chemostat cultivation offers unique possibilities to study the energetic consequences of sugar transport in growing cells. For example, anaerobic, sugar-limited chemostat cultivation has been used to quantify the energy requirement for maltose-proton symport in Saccharomyces cerevisiae. Controlled variation of growth conditions in chemostat cultures can be used to study the differential expression of genes involved in sugar transport and as such can make an important contribution to the ongoing studies on the molecular biology of sugar transport in yeasts.
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