ArticleJournal of virology1995
Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages.International journal of molecular sciences · 2024Article
- Tip110/SART3-Mediated Regulation of NF-κB Activity by Targeting IκBα Stability Through USP15.Frontiers in oncology · 2022Article
- Balance between Retroviral Latency and Transcription: Based on HIV Model.Pathogens (Basel, Switzerland) · 2020Review
- Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis.Current HIV research · 2014Review
- Mouse macrophage innate immune response to Chikungunya virus infection.Virology journal · 2012Article
- Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65.Nucleic acids research · 2012Article
- Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.Retrovirology · 2010Review
- Proteomic analyses of the effects of drugs of abuse on monocyte-derived mature dendritic cells.Immunological investigations · 2009Article
- Article
- Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication.PloS one · 2008Article
- Viral subversion mechanisms in chronic kidney disease pathogenesis.Clinical journal of the American Society of Nephrology : CJASN · 2007Review
- Persistent NF-kappaB activation in renal epithelial cells in a mouse model of HIV-associated nephropathy.American journal of physiology. Renal physiology · 2006Article
- NF-kappaB cis-acting motifs of the human immunodeficiency virus (HIV) long terminal repeat regulate HIV transcription in human macrophages.Journal of virology · 2001Article
- Transcription of the RelB gene is regulated by NF-kappaB.Oncogene · 2001Article
- Ikappakappa mediates NF-kappaB activation in human immunodeficiency virus-infected cells.Journal of virology · 1999Article
- Caprine arthritis encephalitis virus dysregulates the expression of cytokines in macrophages.Journal of virology · 1997Article
- 55- and 75-kilodalton tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiency virus type 1 replication in primary human macrophages.Journal of virology · 1997Article
- Article
- Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription.The Journal of experimental medicine · 1997Article
- The nfkb1 promoter is controlled by proteins of the Ets family.Molecular biology of the cell · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood. Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation. Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in macrophages remains unknown. To further delineate the molecular mechanisms involved in the activation of NF-kappa B in HIV-infected monocytes and macrophages, we have focused on the regulation of the I kappa B molecules. First, we show that persistent HIV infection results in the activation of NF-kappa B not only in monocytic cells but also in macrophages. In HIV-infected cells, I kappa B alpha protein levels are decreased secondary to enhanced protein degradation. This parallels the increased I kappa B alpha synthesis secondary to increased I kappa B alpha gene transcription, i.e., increased RNA and transcriptional activity of its promoter-enhancer. Another protein with I kappa B function, p105, is also modified in HIV-infected cells: p105 and p50 steady-state protein levels are increased as a result of increased synthesis and proteolytic processing of p105. Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif. These results demonstrate the existence of a triple autoregulatory loop in monocytes and macrophages involving HIV, p105 and p50, and MAD3, with the end result of persistent NF-kappa B activation and viral persistence. Furthermore, persistent HIV infection of monocytes and macrophages provides a useful model with which to study concomitant modifications of different I kappa B molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.