ArticleThe Journal of physiology1994
Concentration dependence of neurotransmitter effects on calcium current kinetics in frog sympathetic neurones.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- NaJournal of neurophysiology · 2022Article
- Retinoid receptor-based signaling plays a role in voltage-dependent inhibition of invertebrate voltage-gated CaThe Journal of biological chemistry · 2019Article
- Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells.Journal of cellular and molecular medicine · 2015Article
- Identification of CaV channel types expressed in muscle afferent neurons.Journal of neurophysiology · 2013Article
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels.American journal of physiology. Cell physiology · 2010Article
- Phospholemman modulates the gating of cardiac L-type calcium channels.Biophysical journal · 2010Article
- Neurotransmitter modulation of neuronal calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells.The Journal of physiology · 2003Article
- Attenuation of G protein-mediated inhibition of N-type calcium currents by expression of caveolins in mammalian NG108-15 cells.The Journal of physiology · 2001Article
- G protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins.The Journal of physiology · 2000Article
- Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma.Biophysical journal · 2000Article
- Reluctant gating of single N-type calcium channels during neurotransmitter-induced inhibition in bullfrog sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Kinetic study of N-type calcium current modulation by delta-opioid receptor activation in the mammalian cell line NG108-15.Biophysical journal · 1999Article
- Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels.The Journal of general physiology · 1999Article
- G-Protein-dependent facilitation of neuronal alpha1A, alpha1B, and alpha1E Ca channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Facilitation of rabbit alpha1B calcium channels: involvement of endogenous Gbetagamma subunits.The Journal of physiology · 1998Article
- A reluctant gating mode of glycine receptor channels determines the time course of inhibitory miniature synaptic events in zebrafish hindbrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- On the role of endogenous G-protein beta gamma subunits in N-type Ca2+ current inhibition by neurotransmitters in rat sympathetic neurones.The Journal of physiology · 1998Article
- Mechanisms of modulation of voltage-dependent calcium channels by G proteins.The Journal of physiology · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Noradrenaline (NA) slows the activation kinetics of N-type calcium channels, via G proteins. It has been suggested that the G proteins act by binding directly to the calcium channels. If the slow kinetics reflect binding and unbinding of G proteins, the rates should depend on the concentration of activated G protein. 2. We used different concentrations of NA, and increasing durations of intracellular dialysis with GTP-gamma-S, to vary the concentration of activated G protein. 3. At depolarized potentials (-20 or -10 mV), the slow activation kinetics showed no detectable concentration dependence. This analysis required correction for effects of inactivation on the measured time constants. 4. At -80 mV, reinhibition of calcium channel current was more rapid for larger responses. Thus, the effect appears to be concentration dependent at -80 mV, but not at more depolarized voltages. 5. This voltage dependence is actually expected from kinetic principles: the binding step is rate limiting when the position of equilibrium is toward the bound state (at -80 mV), but not when equilibrium favours unbinding (when the channel is open). 6. During inhibition, the channel appears to 'sense' directly the concentration of the modulator, possibly active G proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.