ArticleThe Journal of physiology1994
5-Hydoxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- Serotonin and the serotonin transporter in the adrenal gland.Vitamins and hormones · 2024Review
- Quipazine Elicits Swallowing in the Arterially Perfused Rat Preparation: A Role for Medullary Raphe Nuclei?International journal of molecular sciences · 2020Article
- Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.Frontiers in physiology · 2020Review
- Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord.PLoS biology · 2018Article
- Physiologic regulation of heart rate and blood pressure involves connexin 36-containing gap junctions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.ACS chemical neuroscience · 2017Review
- 5-Hydroxytryptamine does not reduce sympathetic nerve activity or neuroeffector function in the splanchnic circulation.European journal of pharmacology · 2015Article
- Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.The Journal of physiology · 2014Article
- Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.Frontiers in bioscience (Landmark edition) · 2012Review
- Serotonin and blood pressure regulation.Pharmacological reviews · 2012Review
- Monoaminergic modulation of spinal viscero-sympathetic function in the neonatal mouse thoracic spinal cord.PloS one · 2012Article
- Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice.Neuroscience · 2010Article
- Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata.Journal of chemical neuroanatomy · 2009Review
- Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: effect of olfactory ensheathing glia.The Journal of comparative neurology · 2009Article
- Central pathway for spontaneous and prostaglandin E2-evoked cutaneous vasoconstriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Serotonin potentiates sympathetic responses evoked by spinal NMDA.The Journal of physiology · 2006Article
- Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5-HT.The Journal of physiology · 2006Article
- Medullary raphe neurons facilitate brown adipose tissue activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Plateau potentials and membrane oscillations in parasympathetic preganglionic neurones and intermediolateral neurones in the rat lumbosacral spinal cord.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. Whole-cell recordings were made from seventy-seven identified rat sympathetic preganglionic neurones (SPN) in spinal cord slices. Perfusion of 5-HT (0.5-30 microM) strongly depolarized 90% of neurones. The response was slow in onset, could last over 10 min and was associated with an increase in input resistance. 5-HT could also evoke rhythmical membrane potential oscillations in a population of previously quiescent neurones. 2. The 5-HT response persisted in TTX and also in low-Ca(2+)-high-Mg2+ artificial cerebrospinal fluid (ACSF), suggesting that the receptors are on SPN. The 5-HT uptake inhibitor 6-nitroquipazine potentiated the 5-HT-induced depolarization. 3. The 5-HT-induced depolarization was reduced and then abolished by membrane hyperpolarization to potentials of about -100 mV, but was not reversed in sign by further hyperpolarization. In voltage clamp, 5-HT evoked inward currents associated with the reduction of an outwardly rectifying potassium conductance. 4. The 5-HT2 receptor agonist alpha-methyl-5-HT mimicked the 5-HT response on all neurones, as did the 5-HT1 receptor agonist 5-carboxamidotryptamine (5-CT) on 71% of SPN. The responses to 5-HT, alpha-methyl-5-HT and 5-CT were inhibited by the 5-HT2 antagonists ketanserin and ritanserin. 5. Pressure ejection of 5-HT over the central canal region could evoke a biphasic inhibitory-excitatory response. This response persisted in TTX, suggesting that an inhibitory 5-HT receptor may be located on the medial dendrites. 6. SPN are powerfully depolarized by 5-HT acting at 5-HT2 receptors, via the closure of an outwardly rectifying potassium conductance. The long duration of the response and the ability of 5-HT to induce rhythmical oscillations suggest that 5-HT may have an important role in regulating SPN excitability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.