ArticleClinical and experimental immunology1995
Non-lymphoid and lymphoid cells in acute, chronic and relapsing experimental colitis.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- TNBS colitis induces architectural changes and alpha-synuclein overexpression in mouse distal colon: A morphological study.Cell and tissue research · 2025Article
- Quantitative systems pharmacology model-based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3-kinase inhibitors.CPT: pharmacometrics & systems pharmacology · 2022Article
- SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging.World journal of gastroenterology · 2017Article
- Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Bioluminescence imaging for IL-1β expression in experimental colitis.Journal of inflammation (London, England) · 2013Article
- Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.Immunity · 2010Article
- Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis.BMC genomics · 2008Article
- DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice.The Journal of clinical investigation · 2008Article
- Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis.Digestive diseases and sciences · 2006Article
- Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.The Journal of experimental medicine · 2001Article
- Effects of local budesonide treatment on the cell-mediated immune response in acute and relapsing colitis in rats.Digestive diseases and sciences · 1998Article
- CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rodents migrate to the recipient's colon upon transfer; down-regulation by CD8+ T cells.Clinical and experimental immunology · 1998Article
- Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis.Immunology · 1997Article
- Leukocyte migration in experimental inflammatory bowel disease.Mediators of inflammation · 1997Article
- Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection.Immunology · 1996Article
- Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats.Clinical and experimental immunology · 1995Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In rodents, intracolonic administration of ethanol 30% induces an acute colitis, while administration of 2,4,6-trinitrobenzene sulphonic acid (TNBS) in ethanol induces a longer lasting colitis. In the acute and chronic stages of experimental colitis, lymphoid and non-lymphoid cells were studied in the colon by immunohistochemistry. During the acute inflammation a high damage score of the colon was observed, which was related to an increase in the number of macrophages and granulocytes. Also a change in distributional patterns of macrophage subpopulations was found. The chronic stage of TNBS-ethanol-induced colitis was characterized by an increase in the number of lymphocytes, especially T cells. These data suggest that macrophages and granulocytes are important in the acute phase of experimental colitis, while lymphocytes play a pivotal role in the chronic stage. As most inflammatory bowel disease (IBD) patients have relapses during the chronic disease, we attempted to induce a relapse during experimental colitis by giving a second i.p. or s.c. dose of TNBS. This resulted in increased damage scores of the colon, new areas of ulceration and a further increase in macrophage numbers. No effect on the number of granulocytes was seen. These results indicate that it is possible to mimic relapses in experimental colitis by a second administration of TNBS, and suggest that the rats had been sensitized by the first dose of TNBS, given into the colon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.