ArticleClinical and experimental immunology1995
Tumour necrosis factor-alpha (TNF-alpha) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 125 citations in OpenAlex.
- Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial.PLoS neglected tropical diseases · 2017Trial
- A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment.PLoS neglected tropical diseases · 2011Trial
- Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha (TNF-alpha) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL).Clinical and experimental immunology · 1998Trial
- Pathogenicity and virulence ofVirulence · 2022Review
- Susceptibility and resistance in leprosy: Studies in the mouse model.Immunological reviews · 2021Review
- Host-Related Laboratory Parameters for Leprosy Reactions.Frontiers in medicine · 2021Review
- In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin.PloS one · 2017Article
- The armadillo as a model for peripheral neuropathy in leprosy.ILAR journal · 2014Review
- Gene set signature of reversal reaction type I in leprosy patients.PLoS genetics · 2013Article
- Leprosy: an overview of pathophysiology.Interdisciplinary perspectives on infectious diseases · 2012Article
- Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort.PLoS neglected tropical diseases · 2011Article
- Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India.PLoS neglected tropical diseases · 2011Article
- Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview.Future microbiology · 2011Review
- Granulomatous reactivation during the course of a leprosy infection: reaction or relapse.PLoS neglected tropical diseases · 2010Article
- Reactions following completion of 1 and 2 year multidrug therapy (MDT).The American journal of tropical medicine and hygiene · 2010Article
- Increased Langerhans cell accumulation after mycobacterial stimuli.Histopathology · 2007Article
- Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions.Infection and immunity · 2005Article
- Effects of thalidomide on intracellular Mycobacterium leprae in normal and activated macrophages.Clinical and diagnostic laboratory immunology · 2005Article
- Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor.Infection and immunity · 2004Article
- IgG1 antimycobacterial antibodies can reverse the inhibitory effect of pentoxifylline on tumour necrosis factor alpha (TNF-alpha) secreted by mycobacterial antigen-stimulated adherent cells.Clinical and experimental immunology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Leprosy may be complicated by episodes of increased cell-mediated immunity towards Mycobacterium leprae (reversal reactions) which result in severe local immunopathology in skin lesions and peripheral nerves. Using in situ hybridization and MoAb techniques we have demonstrated TNF-alpha mRNA and TNF-alpha protein in macrophages infiltrating leprosy skin and peripheral nerve. Levels of TNF-alpha mRNA are significantly increased in reactional skin and nerve, particularly in borderline tuberculoid patients. TNF-alpha mRNA and TNF-alpha protein levels are higher in reactional nerves then reactional skin. In both reactional skin and nerve TNF-alpha mRNA is more abundant than TNF-alpha protein; this may reflect the rapid turnover of TNF-alpha protein in an immunologically dynamic situation, such as is seen in reversal reaction. Our findings emphasize the importance of documenting both mRNA and protein production when assessing the role of cytokines in pathology. The leprosy reversal reaction may be regarded as a useful model of tissue immunopathology in which TNF-alpha is generated as part of the host response to infection, but also produces local tissue damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.