ArticleVirchows Archiv : an international journal of pathology1994
Immunohistological detection of the beta subunit of prolyl 4-hydroxylase in rat and mini pig lungs with radiation-induced pulmonary fibrosis.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 14 citations in OpenAlex.
- Surfactant metabolism and anti-oxidative capacity in hyperoxic neonatal rat lungs: effects of keratinocyte growth factor on gene expression in vivo.Histochemistry and cell biology · 2013Article
- Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients.Journal of translational medicine · 2012Article
- Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis.Histochemistry and cell biology · 2008Article
- Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis.Virchows Archiv : an international journal of pathology · 1996Article
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4 authors at 2 institutions in 1 country.
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Abstract
Polyclonal and monoclonal antibodies to the beta subunit of prolyl 4-hydroxylase, the protein disulphide isomerase, were used to compare the pulmonary cells in 13 normal and in 20 fibrotic rat and mini-pig lungs made fibrotic by X-ray irradiation, using the ABC immunoperoxidase technique. In normal lungs, prominent staining of Clara cells and type II pneumocytes and weaker reactivity with alveolar macrophages, fibroblasts, endothelial and smooth muscle cells were detectable. In pulmonary disease, in which interstitial fibrosis was the characteristic feature, the immunoreactivity was increased in both the epithelial and interstitial cells. Type I pneumocytes remained negative. In the early stages of disease (3 to 4 weeks after irradiation) when little morphological alteration was seen, capillary endothelial cells had already become immunoreactive. These results underline the complex involvement and interaction of different lung cell populations in the process of pulmonary fibrogenesis.
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