ArticleVirchows Archiv : an international journal of pathology1994
Oxytocin inhibits proliferation of human breast cancer cell lines.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Intravaginally applied oxytocin improves post-menopausal vaginal atrophy.Post reproductive health · 2015Trial
- Review
- Extracting Knowledge from Machine Learning Models to Diagnose Breast Cancer.Life (Basel, Switzerland) · 2025Article
- Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers.Journal of medicinal chemistry · 2024Review
- Analysis of Breast Cancer Based on the Dysregulated Network.Frontiers in genetics · 2022Article
- Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping.Frontiers in cellular neuroscience · 2022Article
- Love and longevity: A Social Dependency Hypothesis.Comprehensive psychoneuroendocrinology · 2021Review
- Identification of oxytocin-related lncRNAs and assessment of their expression in breast cancer.Scientific reports · 2021Article
- Insulin-Regulated Aminopeptidase in Women with Breast Cancer: A Role beyond the Regulation of Oxytocin and Vasopressin.Cancers · 2020Article
- Review
- Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists.Frontiers in endocrinology · 2020Review
- RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis.Scientific reports · 2019Article
- Greater family size is associated with less cancer risk: an ecological analysis of 178 countries.BMC cancer · 2018Article
- Oxytocin and cancer: An emerging link.World journal of clinical oncology · 2018Review
- Upregulation of Oxytocin Receptor in the Hyperplastic Prostate.Frontiers in endocrinology · 2018Article
- Breast cancer and social environment: getting by with a little help from our friends.Breast cancer research : BCR · 2016Review
- Antiproliferative Effects of Oxytocin and Desmopressin on Canine Mammary Cancer Cells.Frontiers in veterinary science · 2016Article
- Pregnancy-Associated Risk Factors of Postpartum Breast Cancer in Korea: A Nationwide Health Insurance Database Study.PloS one · 2016Article
- Bioinformatics analyses of significant prognostic risk markers for thyroid papillary carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we show that treatment of MDA-MB231 hormone-independent human breast cancer cells with oxytocin (OT) or with the OT analogue F314 induces significant growth inhibition together with a change in cell phenotype. In MCF7 and T47D human breast cancer cells, OT inhibits oestrogen-induced cell growth. In these same cells, OT administration significantly enhances the inhibitory effect of tamoxifen on cell proliferation. MDA-MB231, MCF7 and T47D cells all express mRNA specific for the OT receptor. These data suggest that it may be possible to inhibit breast cancer growth using OT and OT analogues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.