ArticleVirchows Archiv : an international journal of pathology1994
PIP/GCDFP-15 gene expression and apocrine differentiation in carcinomas of the breast.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes.BMC cancer · 2014Trial
- Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis.Scientific reports · 2023Article
- The Prolactin Inducible Protein Modulates Antitumor Immune Responses and Metastasis in a Mouse Model of Triple Negative Breast Cancer.Frontiers in oncology · 2021Article
- Prolactin-induced protein (PIP)-characterization and role in breast cancer progression.American journal of cancer research · 2018Review
- Primary neuroendocrine carcinoma of the breast: report of 2 cases and literature review.Radiology case reports · 2017Article
- Salivary peptidome profiling for diagnosis of severe early childhood caries.Journal of translational medicine · 2016Article
- Prolactin-induced protein as a potential therapy response marker of adjuvant chemotherapy in breast cancer patients.American journal of cancer research · 2016Article
- Locally-advanced primary neuroendocrine carcinoma of the breast: case report and review of the literature.World journal of surgical oncology · 2013Article
- Primary neuroendocrine breast cancer, how much do we know so far?Medical oncology (Northwood, London, England) · 2012Review
- Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer.Breast cancer research : BCR · 2012Article
- Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells.Oncogene · 2007Article
- The enigmatic nature of apocrine breast lesions.Virchows Archiv : an international journal of pathology · 2006Review
- Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast.The American journal of pathology · 2001Article
- The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasis.British journal of cancer · 1999Article
- Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumours.British journal of cancer · 1998Article
- Expression of the PIP/GCDFP-15 gene and survival in breast cancer.Virchows Archiv : an international journal of pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency and the significance of apocrine differentiation in carcinomas of the breast are uncertain, because of the lack of reliable and reproducible criteria for morphological diagnosis. The 15 kDa glycoprotein of cystic breast disease (GCDFP-15) is regarded as a specific functional marker of apocrine cells. Expression of the prolactin-inducible protein (PIP)/GCDFP-15 gene was investigated by Northern blot analysis and in situ hybridization in breast cancer cell lines and in an unselected series (33 cases) of primary carcinomas of the breast. On the same cases, histological assessment of apocrine differentiation and immunocytochemical detection of GCDFP-15 were also performed and correlated with follow-up data. The presence of PIP/GCDFP-15 mRNA was a feature of a relatively high number of cases, but was incompletely correlated with histological and immunocytochemical evidences of apocrine differentiation. Expression of the PIP/GCDFP-15 gene was significantly associated with relapse-free survival, and may represent a novel variable of functional and prognostic relevance.
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