Evidence map›Paper›PMID 7847181›Full record

ArticleAgents and actions1994

Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema.

E de Bernardis, G Leonardi, A Caruso, V M Cutuli, M Amico-Roxas

Abstract read
PubMed Publisher
In one paragraph

Article in Agents and actions, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

E de BernardisInstitute of Pharmacology, University of Catania Medical School, Italy.
G Leonardi
A Caruso
V M Cutuli
M Amico-Roxas
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF. MR-800 exerted a dose-dependent inhibitory activity in all assays, when equimolar doses of sodium salicylate or papaverine were less effective, suggesting the existence of a favourable synergism between salicylate and papaverine.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCantharidinCroton OilDermatitisDose-Response Relationship, DrugEar, ExternalEdemaMaleMicePapaverinePlatelet Activating FactorRatsRats, Sprague-DawleyZymosanAnti-Inflammatory Agents, Non-SteroidalCantharidinCroton OilPapaverinepapaverine salicylatePlatelet Activating FactorZymosan

Identifiers

PMID7847181
OpenAlexW2019042498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.