ArticleActa neurochirurgica1994
Behavioural assessment of pinealectomy and foetal pineal gland transplantation in rats: Part II.
Article in Acta neurochirurgica, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.Cellular and molecular life sciences : CMLS · 2018Article
- Melatonin-based therapeutics for neuroprotection in stroke.International journal of molecular sciences · 2013Review
- Functional reactivity of the dopaminergic system following acute and chronic ketamine treatments.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- The effect of pinealectomy and foetal pineal transplantation of collagen ageing in rats.Acta neurochirurgica · 1996Article
- Morphological assessment in pinealectomy and foetal pineal gland transplantation in rats: Part I.Acta neurochirurgica · 1994Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pineal gland is an endocrine organ which exerts regulatory effects on the activity of various organs and systems. The present study was undertaken to highlight in experimental animals the possible integrative function of this endocrine organ on a behavioural pattern. Pinealectomy and foetal pineal gland transplantation to a subpial cortical area close to the pinealectomized region was performed. Behaviour was defined through motor activity induced by low (2 mg/kg) and high (10 mg/kg) doses of amphetamine in rats. It was shown that pinealectomy produced significant different patterns of behaviour induced by low and high doses of amphetamine. In sham operated animals low dose amphetamine induced a significant locomotor stimulation but without stereotyped activity. High dose amphetamine induced stereotyped activity. After pinealectomy even low dose amphetamine produced the behavioural pattern of stereotyped activity resembling a high dose amphetamine-induced behaviour. This differential effect of amphetamine, seen in pinealectomized rats, was completely restored after transplantation. On the other hand, melatonin treatment did not generate a significant alteration of behavioural profile either in the control or pinealectomized group of rats. Results are discussed with regard to the general regulatory function of the pineal gland.
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