ArticleActa neuropathologica1994
Interphase cytogenetics of glioblastoma and gliosarcoma.
Article in Acta neuropathologica, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Pediatric gliosarcoma, a rare central nervous system tumor in children: Case report and literature review.Heliyon · 2023Article
- Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.Journal of neuro-oncology · 2018Article
- Case of glioblastoma patient treated with tumor treating fields therapy at recurrence degenerating to sarcoma.CNS oncology · 2017Article
- Primary and secondary gliosarcomas: clinical, molecular and survival characteristics.Journal of neuro-oncology · 2015Article
- C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma.Brain tumor pathology · 2015Article
- Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.Brain pathology (Zurich, Switzerland) · 2009Article
- Article
- Gliosarcoma with multiple extracranial metastases: case report and review of the literature.Journal of neuro-oncology · 2007Review
- Neuropathology for the neuroradiologist: fluorescence in situ hybridization.AJNR. American journal of neuroradiology · 2007Review
- Childhood's gliosarcomas: pathological and therapeutical considerations on three cases and critical review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2006Article
- Gliosarcomas: analysis of 11 cases do two subtypes exist?Journal of neuro-oncology · 2005Article
- Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology.Brain pathology (Zurich, Switzerland) · 2002Review
- Genetic profile of gliosarcomas.The American journal of pathology · 2000Article
- Angiogenesis in brain tumors; pathobiological and clinical aspects.Journal of neuro-oncology · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interphase cytogenetics, i.e., in situ hybridization using probes to chromosome-specific DNA, enables histological identification of cells bearing numerical chromosome aberrations and cytogenetic analysis of composite tumors. We studied routinely processed tissues from seven glioblastomas and three gliosarcomas using biotinylated probes to pericentromeric alpha-satellite sequences on chromosomes 10, 17 and X. By applying various pretreatment protocols, an evaluable compromise between morphology and signal intensity was obtained in most cases. Compared to vascular cells with normal chromosomal counts, a significant subpopulation of glioblastoma cells showed monosomy 10 (four of five cases), monosomy 17 (one of seven cases) and loss of one X chromosome (one of seven cases). All monosomy 10 cases comprised additional areas where two copies of chromosome 10 were retained. Among the gliosarcomas, both the glioma and the sarcoma portion showed monosomy 10 in one case and monosomy 17 in another case. In contrast, in the third case of gliosarcoma, monosomy 10 was found only in the glioma portion, whereas a gain of chromosome X was observed in the sarcoma portion. We conclude that: (1) numerical chromosome aberrations can be detected in routinely processed brain tumor biopsy specimens using interphase cytogenetics, making retrospective studies feasible; (2) glioblastomas show intratumoral cytogenetic heterogeneity with formation of monoclonal cell clusters; and (3) sarcoma and glioma elements in gliosarcomas may exhibit the same or different numerical chromosome aberrations, suggesting various histogenetic pathways of the sarcoma-like portion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.