ArticleProceedings of the National Academy of Sciences of the United States of America1995
Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 172 citations in OpenAlex.
- Impact of bacterial vaginosis on sexually transmitted viral infections: a bacterial point of view.FEMS microbiology reviews · 2025Review
- CD83 Regulates the Immune Responses in Inflammatory Disorders.International journal of molecular sciences · 2023Review
- Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease.Periodontology 2000 · 2015Review
- Article
- Gain of function in the immune system caused by a ryanodine receptor 1 mutation.Journal of cell science · 2013Article
- The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.The Journal of experimental medicine · 2007Article
- IL-18-induced CD83+CCR7+ NK helper cells.The Journal of experimental medicine · 2005Article
- Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells.Journal of virology · 2005Article
- Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.Journal of virology · 2004Article
- HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells.Journal of virology · 2002Article
- The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells.The Journal of experimental medicine · 2001Article
- DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.Journal of virology · 2001Article
- HIV-1 infection of placental cord blood monocyte-derived dendritic cells.Journal of hematotherapy & stem cell research · 2001Article
- Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes.Journal of virology · 2001Article
- DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Canarypox virus-induced maturation of dendritic cells is mediated by apoptotic cell death and tumor necrosis factor alpha secretion.Journal of virology · 2000Article
- The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells.Journal of virology · 2000Article
- Unique morphological alterations of the HTLV-I transformed C8166 cells by infection with HIV-1.Pathology oncology research : POR · 2000Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflicting data have been reported with regard to the infectability, dysfunction, and depletion of dendritic cells (DCs) in human immunodeficiency virus (HIV) disease. These discrepancies could potentially be explained by the existence of multiple subsets of cells with dendritic morphology in peripheral blood. The isolation of DCs in humans is accomplished through negative selection until a morphologically pure population is obtained. Recently, DC precursors purified from peripheral blood by negative selection have been observed to develop into functionally and morphologically mature DCs. In this report we identify three populations of cells in peripheral blood that have or can develop a dendritic morphology. The first population, when allowed to mature in culture, develops a dendritic morphology and gains the expression of HB15, a marker of DCs in blood, thymus, skin, and lymphoid organs. The second population expresses HB15 and has the phenotypic and morphologic characteristics of mature DCs. The third population is morphologically very similar to mature DCs but does not share the same T-cell-stimulatory activity and is the only population that is infectable with HIV. Understanding the heterogeneity of cells of dendritic lineage and/or morphology in the peripheral blood will aid in understanding their role as antigen-presenting cells in general and as potential participants in the immunopathogenesis of HIV disease.
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