ArticleProceedings of the National Academy of Sciences of the United States of America1995
Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax.PLoS genetics · 2025Article
- A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases.International journal of molecular sciences · 2021Article
- Shifting roles ofDevelopment (Cambridge, England) · 2019Article
- Targeting HOX/PBX dimers in cancer.Oncotarget · 2017Review
- Hox genes, evo-devo, and the case of the ftz gene.Chromosoma · 2016Review
- Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.The Journal of biological chemistry · 2015Review
- Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications.Frontiers in cell and developmental biology · 2015Article
- Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Article
- Distinct molecular strategies for Hox-mediated limb suppression in Drosophila: from cooperativity to dispensability/antagonism in TALE partnership.PLoS genetics · 2013Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Function and specificity of synthetic Hox transcription factors in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor.Journal of molecular biology · 2009Article
- The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells.Journal of cellular biochemistry · 2009Article
- A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Distinct hox protein sequences determine specificity in different tissues.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Functional evolution of the Ultrabithorax protein.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila homeotic selector (HOM) genes encode a family of DNA binding transcription factors that specify developmental fates of different body segments by differentially regulating the activity of downstream target genes. A central question is how the HOM proteins achieve their developmental specificity despite the very similar DNA binding specificities of isolated HOM proteins in vitro. Specificity could be achieved by differential interactions with protein cofactors. The extradenticle gene might encode such a cofactor since it interacts genetically in parallel with Ultrabithorax, abdominal-A, and perhaps other HOM genes. By using a yeast two-hybrid system, we demonstrate selective interaction of the extradenticle homeodomain protein with certain Ultrabithorax and abdominal-A proteins but not with an Antennapedia protein or a more distant homeodomain protein. Strong interaction with Ultrabithorax proteins requires only the Ultrabithorax homeodomain and a 15-residue N-terminal extension that includes Tyr-Pro-Trp-Met (YPWM), a tetrapeptide motif found near the homeodomain in most HOM proteins and their mammalian Hox counterparts. The size and sequence of the region between the YPWM element and the homeodomain differ among Ultrabithorax isoforms, and this variable region appears to affect the interaction detected in the assay.
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