ArticleProceedings of the National Academy of Sciences of the United States of America1995
A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Preclinical Models of Bladder Cancer: Barrier, Metabolic, and Translational Susceptibility.Pharmaceuticals (Basel, Switzerland) · 2026Review
- NapRNAdb: a multispecies repository and analytical platform for napRNA discovery and functional annotation.Nucleic acids research · 2026Article
- Phenolic Extract from Extra Virgin Olive Oil Induces Different Anti-Proliferative Pathways in Human Bladder Cancer Cell Lines.Nutrients · 2022Article
- Establishment of an optimized orthotopic bladder cancer model in mice.BMC urology · 2022Article
- Animal Models in Bladder Cancer.Biomedicines · 2021Review
- Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.Molecular biology of the cell · 2018Article
- A MAPP Network study: overexpression of tumor necrosis factor-α in mouse urothelium mimics interstitial cystitis.American journal of physiology. Renal physiology · 2018Article
- Insights from animal models of bladder cancer: recent advances, challenges, and opportunities.Oncotarget · 2017Review
- Effects of CYP-Induced Cystitis on Growth Factors and Associated Receptor Expression in Micturition Pathways in Mice with Chronic Overexpression of NGF in Urothelium.Journal of molecular neuroscience : MN · 2016Article
- Intravesical PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in NGF-OE Mice.Journal of molecular neuroscience : MN · 2016Article
- Modelling bladder cancer in mice: opportunities and challenges.Nature reviews. Cancer · 2015Review
- Current animal models of bladder cancer: Awareness of translatability (Review).Experimental and therapeutic medicine · 2014Article
- Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.PloS one · 2014Article
- Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium.Journal of molecular neuroscience : MN · 2012Article
- Exploring molecular genetics of bladder cancer: lessons learned from mouse models.Disease models & mechanisms · 2012Review
- A BAC-based transgenic mouse specifically expresses an inducible Cre in the urothelium.PloS one · 2012Article
- Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium.American journal of physiology. Renal physiology · 2011Article
- PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium.Journal of molecular neuroscience : MN · 2010Article
- Temporally and spatially controllable gene expression and knockout in mouse urothelium.American journal of physiology. Renal physiology · 2010Article
- All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Uroplakins are a group of integral membrane proteins that are synthesized as the major differentiation products of urothelium. The luminal portions of these proteins form 12-nm protein particles arranged in a two-dimensional crystalline array. The expression of uroplakin genes is bladder specific and differentiation dependent; little is known, however, about their molecular regulation. Here we describe the cloning of mouse uroplakin II gene and demonstrate, in transgenic mouse experiments, that a 3.6-kb 5'-flanking sequence of this gene can drive a bacterial lacZ (reporter) gene to express in the suprabasal cell layers of the urothelium. The transgene was not expressed in any tested (nonurothelial) epithelial and other tissues (except hypothalamus). These results suggest that most of the cis elements that confer the bladder-specific and differentiation-dependent expression of mouse uroplakin II gene must reside in the 3.6-kb sequence. The availability of a promoter capable of delivering a foreign molecule to the differentiated cell layers of bladder epithelium opens avenues for studying normal and pathological urothelial differentiation in transgenic mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.