ReviewMolecular and cellular biochemistry1994
Structure, biosynthesis, and function of salivary mucins.
Review in Molecular and cellular biochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 135 citations in OpenAlex.
- An ex vivo salivary lubrication system to mimic xerostomic conditions and to predict the lubricating properties of xerostomia relieving agents.Scientific reports · 2018Trial
- The structural units, recognition factors (RFs) and their codes of a LFuc Recognition Protein (FRP)Glycoconjugate journal · 2026Article
- Oil-based saliva substitutes promote Candida albicans biofilm formation in vitro.BMC oral health · 2025Article
- Heat-Induced Structural Changes in Lactoferrin for Enhanced Mucoadhesion.ACS applied bio materials · 2025Article
- Article
- A comprehensive review of Sjögren's syndrome: Classification criteria, risk factors, and signaling pathways.Heliyon · 2024Review
- Aberrant glycosylation of secretory mucin from the oral cavity in tobacco consumers: a pilot study.Glycoconjugate journal · 2024Article
- The aging lung: microenvironment, mechanisms, and diseases.Frontiers in immunology · 2024Review
- Patients with oral lichen planus display lower levels of salivary acidic glycoproteins than individuals without oral mucosal disease.Clinical oral investigations · 2023Article
- Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern.Antioxidants (Basel, Switzerland) · 2023Article
- A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase fromBiochemistry and biophysics reports · 2021Article
- Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.Nature reviews. Rheumatology · 2021Review
- Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.PloS one · 2021Article
- Mucins as a New Frontier in Pulmonary Fibrosis.Journal of clinical medicine · 2019Review
- Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia.International journal of molecular sciences · 2019Review
- A detection and quantification label-free tool to speed up downstream processing of model mucins.PloS one · 2018Article
- Galectin-1 binds mucin in human trophoblast.Histochemistry and cell biology · 2014Article
- Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells.PloS one · 2014Article
- Characterization of novel O-glycans isolated from tear and saliva of ocular rosacea patients.Journal of proteome research · 2013Article
- Characterising the dynamics of expirated bloodstain pattern formation using high-speed digital video imaging.International journal of legal medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glandular secretions of the oral cavity lining the underlying buccal mucosa are highly specialized fluids which provide lubrication, prevent mechanical damage, protect efficiently against viral and bacterial infections, and promote the clearance of external pollutants. This mucus blanket contains large glycoproteins termed mucins which contribute greatly to the viscoelastic nature of saliva and affect its complex physiological activity. The protein core of mucins consists of repetitive sequences, rich in O-glycosylated serine and threonine, and containing many helix-breaking proline residues. These features account for the extended, somewhat rigid structure of the molecule, a high hydrodynamic volume, its high buoyant density, and high viscosity. The oligosaccharide moiety of salivary mucins accounts for up to 85% of their weight. The oligosaccharide side chains exhibit an astonishing structural diversity. The isolation, composition, structure, molecular characteristics, and functional relevance of salivary mucins and their constituents is discussed in relation to recent advancements in biochemistry and molecular biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.