ArticleEuropean journal of pediatrics1994
Sodium chloride deficiency in cystic fibrosis patients.
Article in European journal of pediatrics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Electrolyte abnormalities in cystic fibrosis: systematic review of the literature.Pediatric nephrology (Berlin, Germany) · 2014Pooled it
- Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis.The Journal of pediatrics · 2009Guideline
- Exocrine Pancreatic Insufficiency in Children - Challenges in Management.Pediatric health, medicine and therapeutics · 2023Review
- "Summer hypokalemia" as an initial presentation of cystic fibrosis in a morbidly obese African American adult: case report.BMC nephrology · 2020Article
- Optical Nanosensors forAnalytical methods : advancing methods and applications · 2020Article
- A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes.The Journal of biological chemistry · 2019Article
- Nanoduct sweat conductivity measurements in 2664 patients: relationship to age, arterial blood gas, serum electrolyte profiles and clinical diagnosis.Journal of clinical medicine research · 2013Article
- Primary molecular disorders and secondary biological adaptations in bartter syndrome.International journal of nephrology · 2011Article
- Newborn screening for cystic fibrosis.Clinical reviews in allergy & immunology · 2008Review
- An epidemic of pseudo-Bartter syndrome in cystic fibrosis patients.European journal of pediatrics · 2008Article
- Metabolic alkalosis with hypo-electrolytaemia or pseudo-Bartter syndrome as a presentation of cystic fibrosis in infancy. Discription of three cases.European journal of pediatrics · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium chloride deficiency (SCD) was observed within the 1st year of life in 12 of 46 cystic fibrosis (CF) patients between July 1989 and September 1992. All patients showed sweating, loss of appetite, fever, vomiting, irritation, dehydration, weakness, and cyanosis during an attack. Mean plasma sodium, potassium and chloride levels were 122.9 (range 106-135), 2.5 (range 1.6-3.5), and 73.3 (range 60-90) mEq/l respectively. Alkalosis and elevated plasma renin activity were detected in all patients. Of the patients, 50% showed microscopic haematuria, and hypercalciuria was detected in two out of four patients. Low urinary sodium and high urinary potassium were observed in the four examined patients. Increased creatinine, BUN and uric acid values returned to normal with treatment. All the patients were treated initially with intravenous fluids and electrolyte solutions. All patients were less than 7 months of age during the first attack, five received only breast milk and the others breast milk with formula milk. Their oral salt supplement was 2-4 mEq/kg per day, which is recommended for CF patients, but could be deficient in excessively sweating infants. The genotype of these patients might be cause of high salt losses. F508 is the most common mutation with the frequency of 38% in our CF patients with SCD, but the frequency of unknown mutations is high (54%).
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