ArticleThe Journal of experimental medicine1995
Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 105 citations in OpenAlex.
- A randomized placebo-controlled trial of lisofylline in HLA-identical, sibling-donor, allogeneic bone marrow transplant recipients. The Lisofylline Marrow Transplant Study Group.Bone marrow transplantation · 2000Trial
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- Post-COVID-19 disruption of the respiratory microbiome modulatesEmerging microbes & infections · 2025Article
- Phosphatidylethanolamines link ferroptosis and autophagy during appressorium formation of rice blast fungus.Molecular plant pathology · 2024Article
- JNK signaling as a target for anticancer therapy.Pharmacological reports : PR · 2021Review
- Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice.European journal of drug metabolism and pharmacokinetics · 2016Article
- Potential Metabolic Biomarkers to Identify Interstitial Lung Abnormalities.International journal of molecular sciences · 2016Article
- Basic Shock Physiology and Critical Care.The veterinary clinics of North America. Exotic animal practice · 2016Review
- Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide-induced acute lung injury during neutropenia recovery.Critical care (London, England) · 2013Article
- Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.Vascular medicine (London, England) · 2012Article
- Effect of phosphatidylcholine on pld gene expression level of Aspergillus fumigatus by the real time PCR method and investigations of these genes using bioinformatics analysis.Iranian journal of microbiology · 2012Article
- CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.Diabetes · 2012Article
- Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?Annals of intensive care · 2011Article
- Review
- Therapeutic potentials of pentoxifylline for treatment of cardiovascular diseases.Experimental and clinical cardiology · 2004Article
- Immunotherapy of inflammatory demyelinating diseases of the central nervous system.Immunologic research · 2001Review
- Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC).Journal of molecular neuroscience : MN · 1999Article
- Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion.The Journal of experimental medicine · 1999Article
- Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock.The Journal of experimental medicine · 1998Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Because phosphatidic acid (PA) pathway signaling may mediate many basic reactions involving cytokine-dependent responses, we investigated the effects of CT1501R, a functional inhibitor of the enzyme lysophosphatidic acid acyltransferase (LPAAT) which converts lysophosphatidic acid (Lyso-PA) to PA. We found that CT1501R treatment not only prevented hypoxia-induced PA increases and lyso-PA consumption in human neutrophils, but also prevented neutrophil chemotaxis and adherence in vitro, and lung injury and lung neutrophil accumulation in mice subjected to hemorrhage and resuscitation. In addition, CT1501R treatment prevented increases in mRNA levels and protein production of a variety of proinflammatory cytokines in multiple lung cell populations after blood loss and resuscitation. Our results indicate the fundamental role of PA metabolism in the development of acute inflammatory lung injury after blood loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.