ArticleThe EMBO journal1995
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 313 citations in OpenAlex.
- Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.Apoptosis : an international journal on programmed cell death · 2020Article
- Protective effects of cytokine combinations against the apoptotic activity of glucocorticoids on CD34Cytotechnology · 2019Article
- Transcription factor and microRNA-regulated network motifs for cancer and signal transduction networks.BMC systems biology · 2015Article
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- E4BP4 is a cardiac survival factor and essential for embryonic heart development.Molecular and cellular biochemistry · 2010Article
- Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.The Journal of biological chemistry · 2010Article
- Tnk1/Kos1: a novel tumor suppressor.Transactions of the American Clinical and Climatological Association · 2010Review
- Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway.The Journal of biological chemistry · 2009Article
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- Interleukin-3 prevents neuronal death induced by amyloid peptide.BMC neuroscience · 2007Article
- Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.Oncogene · 2005Article
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- Cytokine-mediated cell survival.International journal of hematology · 2004Review
- Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors.Molecular and cellular biology · 2004Article
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- Interleukin-3 receptors in Hodgkin's disease.The American journal of pathology · 2003Article
- Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) exert their biological functions through acting on a specific receptor which consists of a ligand-specific alpha subunit and the shared common beta subunit. Inhibition by genistein of a subset of IL-3/GM-CSF-mediated signals, including c-myc induction, resulted in the abrogation of DNA synthesis, however, IL-3 still protected cells from apoptotic cell death. Conversely, a C-terminal truncated form of the GM-CSF receptor, which is missing a critical cytoplasmic region required for activation of the Ras/Raf-1/MAP kinase pathway, induced DNA synthesis, but failed to prevent cell death in response to GM-CSF. Consequently, cells died by apoptosis in the presence of GM-CSF, despite displaying a transient mitogenic response. However, expression of activated Ras protein complemented defective signalling through the mutant receptor and supported long-term proliferation in concert with GM-CSF. These results indicate that IL-3 and GM-CSF prevent apoptosis of hematopoietic cells by activating a signalling pathway distinct from the induction of DNA synthesis and that long-term cell proliferation requires the activation of both pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.