ArticleAnnals of surgical oncology1994
Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.
Article in Annals of surgical oncology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 86 citations in OpenAlex.
- Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas.Cancer · 2012Trial
- Clinical and Molecular Insights of Radiation-Induced Breast Sarcomas: Is There Hope on the Horizon for Effective Treatment of This Aggressive Disease?International journal of molecular sciences · 2022Review
- Interrogating the Genomic Landscape of Uterine Leiomyosarcoma: A Potential for Patient Benefit.Cancers · 2022Review
- Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell lines.Gynecologic oncology research and practice · 2014Article
- Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden.PloS one · 2014Article
- Phase I trial of preoperative chemoradiation plus sorafenib for high-risk extremity soft tissue sarcomas with dynamic contrast-enhanced MRI correlates.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- New drugs and combinations for the treatment of soft-tissue sarcoma: a review.Cancer management and research · 2012Article
- Evolving therapies and FAK inhibitors for the treatment of cancer.Anti-cancer agents in medicinal chemistry · 2010Review
- Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.Cell cycle (Georgetown, Tex.) · 2010Article
- Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase.Molecular carcinogenesis · 2009Article
- TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements.Biochimica et biophysica acta · 2009Article
- Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.Cancer research · 2008Article
- Cellular responses to substrate topography: role of myosin II and focal adhesion kinase.Biophysical journal · 2006Article
- New therapeutic strategies for soft tissue sarcomas.Current treatment options in oncology · 2003Review
- Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis.The Biochemical journal · 2003Article
- Biological properties and gene expression associated with metastatic potential of human osteosarcoma.Clinical & experimental metastasis · 2003Article
- Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones.Cell stress & chaperones · 2001Review
- Focal adhesion kinases: interest in immunoendocrinology, developmental biology, and cancer.Endocrine · 2000Review
- Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.Molecular and cellular biology · 1999Article
- Analysis of signaling protein kinases in human colon or colorectal carcinomas.Digestive diseases and sciences · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe tyrosine kinases are a family of genes that includes many growth factor receptors and protooncogenes. They appear to have a role in many cancers, but have not been systematically studied in the pathogenesis and progression of human sarcomas.
methodsTo characterize the protein tyrosine kinases that are expressed in human sarcomas, we used a polymerase chain reaction (PCR)-based method to construct kinase-specific cDNA libraries from low-grade and high-grade primary tumors. Thereafter, individual tyrosine kinase gene expression was assessed in a panel of sarcoma cell lines and primary tumors using Northern blotting and PCR.
resultsWe identified 19 species of tyrosine kinase genes, including many growth factor receptors, the human homolog of the focal adhesion kinase (FAK) gene, and a novel trk-related kinase designated HGK2. Messenger RNA expression analyses showed relative overexpression of the two forms of the platelet-derived growth factor receptors (PDGFRs) with expression of the alpha form restricted to a subgroup of high-grad and metastatic sarcomas. We were unable to demonstrate coexpression of the PDGF isoforms in primary tumors that overexpressed the receptors, suggesting that a PDGF/PDGFR autocrine pathway may not be a central mechanism in the malignant transformation of sarcomas in vivo. FAK expression was observed in a variety of sarcomas, with increased levels in several high-grade and metastatic leiomyosarcomas.
conclusionsWhen grouped together by histologic cell type and grade, the expression data of the 19 kinases in primary tumors described a greater degree of heterogeneity than is generally appreciated by clinicopathologic classification schemes. This diversity suggests that sarcomas, even those that appear to be clinically similar, arise through a variety of molecular pathways involving tyrosine kinases.
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