ArticleBritish journal of pharmacology1994
Release of Ca2+ from intracellular store in smooth muscle cells of rat portal vein by ATP-induced Ca2+ entry.
Article in British journal of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism.Frontiers in bioscience : a journal and virtual library · 2008Review
- Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladder.The Journal of physiology · 2000Article
- Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra.The Journal of physiology · 1999Article
- Calcium handling and purinoceptor subtypes involved in ATP-induced contraction in rat small mesenteric arteries.The Journal of physiology · 1996Article
- Depolarization-evoked increases in cytosolic calcium concentration in isolated smooth muscle cells of rat portal vein.The Journal of physiology · 1996Article
- Rise in cytosolic Ca2+ concentration induced by P2-purinoceptor activation in isolated myocytes from the rat gastrointestinal tract.British journal of pharmacology · 1996Article
- Mechanism of the ATP-induced rise in cytosolic Ca2+ in freshly isolated smooth muscle cells from human saphenous vein.Pflugers Archiv : European journal of physiology · 1995Article
- Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes.The Journal of physiology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The action of adenosine 5'-triphosphate (ATP, 10 microM) was studied in single patch-clamped smooth muscle cells of rat portal vein where the free internal Ca2+ concentration in the cell (Cai) was estimated by the emission from the dye indo-1. 2. In the presence of 20 microM gallopamil (D600), a blocker of voltage-dependent Ca2+ channels, ATP applied to cells held at a holding potential of -60 mV evoked a transient inward current and an increase in Cai. 3. The rise in Cai evoked by ATP was completely suppressed in the absence of external Ca2+ although a transient inward current was still observed. 4. ATP-induced responses were not modified by the addition of the inositol 1,4,5-trisphosphate receptor antagonist, heparin (1 mM) in the pipette solution. 5. In the presence of caffeine (5 mM) or ryanodine (100 microM) in the pipette solution, which deplete the intracellular Ca2+ store, the ATP-induced Cai rise was greatly reduced. 6. Our results suggest that in single cells from rat portal vein, ATP releases Ca2+ from intracellular stores without involving InsP3, but via a Ca2+ release mechanism activated by Ca2+ influx through ATP-gated channels.
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