ReviewDrugs & aging1994
The role of interleukin-6 in certain age-related diseases.
Review in Drugs & aging, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 83 citations in OpenAlex.
- The Stress and Adversity Inventory for Adults (Adult STRAIN) in German: An overview and initial validation.PloS one · 2019Trial
- Dynamic cytokine monitoring enhances CAP severity scores in elderly patients: a prospective pilot study.Internal and emergency medicine · 2026Observational
- Efficacy of a paper-based interleukin-6 test strip combined with a spectrum-based optical reader for sequential monitoring and early recognition of respiratory failure in elderly pneumonia-a pilot study.Frontiers in pharmacology · 2023Article
- Remodeling the Microenvironment before Occurrence and Metastasis of Cancer.International journal of biological sciences · 2019Review
- Sleep and inflammation in resilient aging.Interface focus · 2014Review
- Angiotensin II induces cell growth and IL-6 mRNA expression through the JAK2-STAT3 pathway in rat cerebellar astrocytes.JAK-STAT · 2012Article
- Inflammatory markers in population studies of aging.Ageing research reviews · 2011Review
- Reactive astrocytes as therapeutic targets for CNS disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
- Innate immunity and aging.Experimental gerontology · 2008Review
- Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.Nature reviews. Immunology · 2008Review
- [The elderly patient--who is that?].Der Internist · 2007Article
- Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- [The concept of frailty--from phenomenology to therapeutic approaches].Zeitschrift fur Gerontologie und Geriatrie · 2005Article
- Survival and cell mediated immunity after burn injury in aged mice.Journal of the American Aging Association · 2002Article
- Physiological and pathological roles of interleukin-6 in the central nervous system.Molecular neurobiology · 1997Review
- Determinants of health and disease.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Interleukin-6 (IL-6) is a pro-inflammatory cytokine with a wide range of functions. Perhaps the most important physiologically is its role as a mediator of the acute phase inflammatory response. Normally, there is little measurable IL-6 in the circulation, but levels increase abruptly to nanogram amounts during an inflammatory process. During aging, it has been proposed that the tight regulation of IL-6 gene expression becomes less effective and levels are measurable even when there is no evidence for inflammation. Several investigators have identified this cytokine as being involved in the pathogenesis of various disease processes and we have suggested that certain age-associated diseases are directly related. Among these are late-life lymphoma and myeloma, osteoporosis and possibly Alzheimer's disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.