ArticleProceedings of the National Academy of Sciences of the United States of America1995
Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Human Blood IgAEuropean journal of immunology · 2026Article
- The malignant transformation potential of the oncogene STYK1/NOK at early lymphocyte development in transgenic mice.Biochemistry and biophysics reports · 2024Article
- Genome-scale CRISPR activation screen uncovers tumor-intrinsic modulators of CD3 bispecific antibody efficacy.Scientific reports · 2019Article
- Coexpression of CD5 and CD43 predicts worse prognosis in diffuse large B-cell lymphoma.Cancer medicine · 2018Article
- Intracellular patterns of sialophorin expression define a new molecular classification of breast cancer and represent new targets for therapy.British journal of cancer · 2014Article
- Comparative analyses of B cell populations in trout kidney and mouse bone marrow: establishing "B cell signatures".Developmental and comparative immunology · 2010Article
- Article
- Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.The Biochemical journal · 2005Article
- Overexpression of leukocyte marker CD43 causes activation of the tumor suppressor proteins p53 and ARF.Oncogene · 2004Article
- Reduced CD43 expression on the neutrophils of MDS patients correlates with an activated phenotype of these cells.International journal of hematology · 2001Article
- CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA.Nucleic acids research · 2000Article
- Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment.The Journal of experimental medicine · 2000Article
- CD43, a molecule with multiple functions.Immunologic research · 1999Review
- Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leukosialin (also known as Ly48, CD43, and sialophorin) is a major cell surface sialoglycoprotein found on a variety of hematopoietically derived cells. The precise function of this molecule is poorly understood but it has been implicated in cell proliferation and intercellular adhesion. We developed a transgenic mouse model to assess leukosialin's function in vivo. Our approach was to alter mouse CD43 (mCD43) expression in the B-cell lineage where it is tightly regulated, by expressing it in peripheral B cells where it is normally absent. To drive expression of leukosialin in mature B cells, the immunoglobulin heavy chain enhancer was fused to the mCD43 gene. mCD43-immunoglobulin heavy chain enhancer transgenic mice display splenomegaly due to increased numbers of B cells. Transgenic B cells show a striking increase in their ability to survive in vitro compared to B cells from nontransgenic control mice. This prolonged survival is reflected in a decreased susceptibility to apoptosis. These observations suggest that mCD43 plays an important role in the regulation of B-cell survival. The alteration of the temporal expression, or "disregulation," of a gene in transgenic mice provides a general strategy for elucidating the in vivo role of other molecules involved in cell signaling and adhesion.
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