ArticleProceedings of the National Academy of Sciences of the United States of America1995
The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 89 citations in OpenAlex.
- Calming the Nerves via the Immune Instructive Physiochemical Properties of Self-Assembling Peptide Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding.Frontiers in molecular neuroscience · 2024Review
- Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder.Frontiers in psychiatry · 2022Review
- NCAM1 is the Target of miRNA-572: Validation in the Human Oligodendroglial Cell Line.Cellular and molecular neurobiology · 2018Article
- Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means.Current opinion in solid state & materials science · 2014Article
- Neuronal influence behind the central nervous system regulation of the immune cells.Frontiers in integrative neuroscience · 2013Review
- Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases.Journal of cancer research and clinical oncology · 2011Article
- Gliogenesis and glial pathology in depression.CNS & neurological disorders drug targets · 2007Review
- The polysialylated neural cell adhesion molecule promotes neurogenesis in vitro.Neurochemical research · 2006Article
- Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.Molecular and cellular biology · 2005Article
- Cultured rat hippocampal neural progenitors generate spontaneously active neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner.Molecular and cellular biology · 1999Article
- KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development.The Journal of cell biology · 1998Article
- Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family.The Journal of cell biology · 1997Article
- Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Density-dependent feedback inhibition of oligodendrocyte precursor expansion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell proliferation is a key primary process during neural development and also plays an important role in the regenerative response of neural tissue to injury. It has been reported that glial cell proliferation is, at least in part, controlled by a neuronal signal, possibly involving cell surface molecules. We report here that the addition of purified rat neural cell adhesion molecule (N-CAM) to primary cultures of rat forebrain astrocytes inhibits their proliferation. This inhibitory effect can be elicited in cultures grown in chemically defined serum-free medium or in medium that had been supplemented with growth factors. Polyclonal antibodies to N-CAM or their Fab' fragments elicited a similar inhibitory effect. The magnitude of the inhibitory effect of N-CAM was dependent on cell density: it was maximal at low cell densities and weakened progressively as cells approached confluency. Synthetic peptides with sequences identical to a putative homophilic binding region of N-CAM mimicked the effect of purified N-CAM, while peptides of the same length and amino acid composition but with a randomized sequence did not. The addition of N-CAM antisense oligonucleotides to primary astrocyte cultures for 48 h resulted in reduced levels of N-CAM expression. After N-CAM levels on astrocytes were diminished by this treatment, the antiproliferative effect of N-CAM added to the medium was significantly reduced. The combined results suggest that N-CAM homophilic binding may be involved in the control of glial cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.