ArticleProceedings of the National Academy of Sciences of the United States of America1995
Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
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- Binding Revisited-Avidity in Cellular Function and Signaling.Frontiers in molecular biosciences · 2020Review
- Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms.Journal of the American Chemical Society · 2019Article
- Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.Brain : a journal of neurology · 2015Article
- Design of surface modifications for nanoscale sensor applications.Sensors (Basel, Switzerland) · 2015Review
- Retinoic acid actions through mammalian nuclear receptors.Chemical reviews · 2014Review
- Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.Nucleic acids research · 2012Article
- Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.The Journal of biological chemistry · 2011Article
- Molecular assembly for high-performance bivalent nucleic acid inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research · 2001Article
- Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.Genes & development · 2000Article
- Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors.Molecular and cellular biology · 1998Article
- Retinoid X receptor alpha forms tetramers in solution.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nuclear hormone receptors are ligand-regulated transcription factors that function in metazoan homeostasis and differentiation. We report here that DNA recognition by at least one class of nuclear receptors, the retinoid X receptors (RXRs), can occur through an unanticipated mechanism involving the cooperative formation of protein tetramers and other high-order oligomers. Formation of these oligomeric complexes enables RXRs alpha and gamma, but not beta, to efficiently regulate transcription through response elements poorly recognized by RXR dimers. Thus, oligomer formation plays an important role in determining the specificity of DNA recognition by nuclear receptors and contributes to isoform-dependent differences in gene regulation.
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Registered trials
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