ArticleGenetics1994
Genetic epilepsy model derived from common inbred mouse strains.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Hidden in plain sight: spike-wave discharges in mouse inbred strains.Genes, brain, and behavior · 2014Article
- A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.Human molecular genetics · 2011Article
- Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats.Trends in genetics : TIG · 2009Review
- Loss of astrocytic domain organization in the epileptic brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A major effect QTL determined by multiple genes in epileptic EL mice.Genome research · 2000Article
- Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Mapping murine loci for seizure response to kainic acid.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- New seizure frequency QTL and the complex genetics of epilepsy in EL mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The recombinant inbred mouse strain, SWXL-4, exhibits tonic-clonic and generalized seizures similar to the commonest epilepsies in humans. In SWXL-4 animals, seizures are observed following routine handling at about 80 days of age and may be induced as early as 55 days by rhythmic gentle tossing. Seizures are accompanied by rapid, bilateral high frequency spike cortical discharges and followed by a quiescent post-ictal phase. Immunohistochemistry of the immediate early gene products c-Fos and c-Jun revealed abnormal activation within cortical and limbic structures. The seizure phenotype of SWXL-4 can be explained and replicated fully by the inheritance of susceptibility alleles from its progenitor strains, SWR/J and C57L/J. Outcrosses of SWXL-4 with most other common inbred strains result in F1 hybrids that have seizure at least as frequently as SWXL-4 itself. Quantitative trait locus mapping reveals a seizure frequency determinant, Szf1, near the pink-eyed dilution locus on chromosome 7, accounting for up to 32% of the genetic variance in an F2 intercross between SWXL-4 and the linkage testing strain ABP/Le. These studies demonstrate that common strains of mice such as SWR and C57L contain latent epilepsy susceptibility alleles. Although the inheritance of susceptibility may be complex, these results imply that a number of potentially important and practical, noninvasive models for this disorder can be constructed and studied in crosses between common mouse strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.