ArticleGenetics1994
Mutations in calphotin, the gene encoding a Drosophila photoreceptor cell-specific calcium-binding protein, reveal roles in cellular morphogenesis and survival.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Vitamin A deficiency affects gene expression in the Drosophila melanogaster head.G3 (Bethesda, Md.) · 2021Article
- Differential Gene Expression in Red Imported Fire Ant (Insects · 2018Article
- Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors.BMC neuroscience · 2018Article
- Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.Developmental biology · 2008Article
- Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.PLoS genetics · 2007Article
- Calcium binding to an elastic portion of connectin/titin filaments.Journal of muscle research and cell motility · 2001Article
- The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis.Molecular and cellular biology · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Calphotin is a Drosophila photoreceptor cell-specific protein expressed very early in eye development, at the time when cell-type decisions are being made. Calphotin is a very hydrophobic and proline-rich protein which lacks obvious transmembrane domains. The cDNA encoding Calphotin was mapped to a region removed by a set of existing chromosomal deletions. Mutations that alter photoreceptor cell structure and development were isolated that fail to complement these deletions. These mutations fall into two classes. Class I mutations alter the structure of the rhabdomere, a photoreceptor cell organelle specialized for phototransduction. Class II mutations have rough eyes, due to misorientation of the rhabdomeres and photoreceptor cell death. Transformation rescue of these phenotypes in transgenic flies bearing calphotin genomic DNA indicates that both classes of mutations are in the calphotin gene. Analysis of these mutations suggest that Calphotin plays important roles in both rhabdomere development and in photoreceptor cell survival.
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